Endorectal Ultrasound
Endorectal ultrasound
Definition
Ultrasound is a type of imaging technique that pain-lessly uses sound waves to produce an image of internal structures, organs, and masses. Endorectal ultrasound, also called transrectal ultrasound, is a special ultrasound technique in which the transducer is directly inserted through the anus and into the patient's rectum. The sound wave echoes detected by the transducer are converted by a computer into an image.
Purpose
Ultrasound technology has been used in medicine since World War II and is recognized as a non-invasive, non-radiative, real-time and inexpensive imaging capacity. It has become standard medical practice to produce fetal images and to identify and assess various anatomical features of the body.
Endorectal ultrasound is a specialized ultrasound application and it represents one of the most useful diagnostic
tools for diseases of the anal and rectal regions of the body, especially for rectal, anal, and prostrate cancer screening and staging.
For rectal cancer , endorectal ultrasound is the most preferred method for staging both depth of tumor penetration and local lymph node metastatic status. Endorectal ultrasound:
- differentiates areas of invasion within large rectal adenomas that seem benign
- determines the depth of tumor penetration into the rectal wall
- determines the extent of regional lymph node invasion
- can be combined with other tests (chest x rays and computed tomography scans, or CT scans) to determine the extent of cancer spread to distant organs, such as the lungs or liver
The resulting rectal cancer staging allows physicians to determine the need for—and order of—radiation, surgery, and chemotherapy .
For patients diagnosed with anal cancer , endorectal ultrasound may help to stage the lesion and may be used as follow-up care to check for recurrence of cancer after treatment.
In the diagnosis of prostrate cancer, endorectal ultrasound has become a companion technique to digital rectal examination (DRE). It is also the most frequent method used to guide biopsy needle insertion. If surgery is indicated, endorectal ultrasound can also assist the pre-operative evaluation of the depth of cancer penetration and of the presence of metastases, as required to design appropriate surgical procedures.
Endorectal ultrasounds can also be used to check the overall treatment results.
Precautions
This is a very easy procedure. Unlike other imaging techniques, it uses no radiation and thus requires no special precautions.
Description
The instrumentation used for endorectal ultrasound consists of a hand-held probe, the transrectal transducer, a scanner, and an imaging screen. During the procedure, high-frequency acoustical (sound) waves are sent out by the small microphone-like transducer, which is inserted into the rectum. The waves bounce off the organ being examined and produce echoes sent by the transducer to a computer so as to generate a picture called a sonogram. Doctors examine the sonogram for echoes that may represent abnormal areas.
Usually, the patient lies on his side during the test. An endorectal probe is covered with a protective covering and inserted into the patient. The probe looks like a small enema tip and there is a minimal amount of discomfort associated with the procedure itself. Once inserted, the sonographer or radiologist gently moves the probe forward and backward to best evaluate the organ being examined. An endorectal ultrasound generally takes five to ten minutes. After the procedure, the radiologist interprets the results and sends a report to the referring physician.
Preparation
The patient requires no anesthetic or sedation, but needs an enema about two hours before the test in order to provide a clean rectal wall through which to scan. The
evening before the procedure, it is recommended that the patient eat a small dinner, drinking only clear liquids and avoiding coffee, tea, or soft drinks after dinner.
Aftercare
The patient should enjoy a good meal and remember to keep a follow-up appointment if scheduled. In some cases, there may be some bleeding from the rectum, though this usually settles within a few days. Antibiotics may be prescribed in some cases.
Risks
Multiple studies have shown that the sound waves used with ultrasound imaging are harmless and may be directed at patients with complete safety. However, some patients may develop infections following the procedure, which could require further treatment. These may cause shivering and fever . Any manifestation of such symptoms should be immediately reported to the treating physician. Generally speaking, the entire procedure is well tolerated and there is usually minimal bleeding afterwards.
Normal results
Normal sonograms produce images that have the correct shape of the organ or tissue examined by the procedure, meaning that it corresponds to the true anatomy.
Abnormal results
Abnormal sonograms produce images which highlight abnormal features of the organ being scanned. In a tumor is present, it will show up as a distinct contrast feature on the sonogram.
See Also Imaging studies
Resources
BOOKS
Bankman, I. Handbook of Medical Imaging. Academic Press, 2000
Bushong, S. C. Diagnostic Ultrasound. New York: McGraw-Hill & Co., 1999.
Edelstein, Peter, M.D. Colon and Rectal Cancer. New York: Wiley-Liss, 2000.
PERIODICALS
Gavioli, M., A. Bagni, I. Piccagli, S. Fundaro, G. Natalini. "Usefulness of endorectal ultrasound after preoperative radiotherapy in rectal cancer: comparison between sono-graphic and histopathologic changes." Diseases of the Colon and Rectum 43 (August 2000):1075-83.
Hsieh, J.-S., C.-J. Huang, J.-Y. Wang, T.-J. Huang. "Benefits of Endorectal Ultrasound for Management of Smooth-Muscle Tumor of the Rectum." Diseases of the Colon and Rectum 42 (August 1999):322-8
Ott, D. J. "EUS and rectal cancer staging." American Journal of Gastroenterology 93 (April 1998):659-60.
Saclarides, T. J. "Endorectal ultrasound." Surgical Clinics of North America 78 (April 1998):237-49.
Sudhanshu, G. et al. "Staging of prostate cancer using 3-dimensional transrectal ultrasound images: a pilot study." Journal of Urology 162 (1999):1318-1321.
van den Berg, J. C., J. P. van Heesewijk, H. W. van Es. "Malignant stromal tumour of the rectum: findings at endorectal ultrasound and MRI." British Journal of Radiology 73 (September 2000):1010-12.
Monique Laberge, Ph.D.
KEY TERMS
Anal
—Pertaining to the anus, which is the terminal orifice of the digestive—or alimentary—canal.
Anatomy
—Structure of the body and of the relationship between its parts.
Biopsy
—Procedure that involves obtaining a tissue specimen for microscope analysis to establish a precise diagnosis.
Cancer screening
—Examination of people to detect early stages in the development of cancer even though they have no symptoms.
Colon
—Large intestine.
Digital rectal examination (DRE)
—Examination performed by a physician to detect rectal cancer. The physician inserts a gloved, lubricated finger into the rectum of the patient and feels for abnormal areas.
Endorectal probe
—Instrument which sends sound waves through the prostrate. Sound echoes are then recorded as an image.
Enema
—Injection of a liquid into the rectum.
Metastasis
—The transfer of cancer from one part of the body to another not directly connected with it.
Rectal
—Pertaining to the rectum, which is the last portion of the large intestine.
Sonogram —A computer picture of areas inside the body created by bouncing sound waves off organs and other tissues. Also called ultrasono-gram or ultrasound.
QUESTIONS TO ASK THE DOCTOR
- How many endorectal ultrasounds will I have to undergo?
- Are any other imaging tests indicated?
- How will this test help you diagnose my cancer?
Cite this article
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Mammalian Cysteine Metabolism: New Insights into Regulation of Cysteine Metabolism1,2
Magazine article from: The Journal of Nutrition; 6/1/2006; ; 700+ words
; ...The mammalian liver tightly regulates its free cysteine pool, and intracellular cysteine in rat liver is maintained between 20 and 100...intakes are deficient or excessive. By keeping cysteine levels within a narrow range and by regulating...
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Dietary Cysteine Reduces the Methionine Requirement by an Equal Proportion in Both Parenterally and Enterally Fed Piglets1,2
Magazine article from: The Journal of Nutrition; 12/1/2003; ; 700+ words
; ...amino acids (SAA), methionine and cysteine, are normally supplied in a 50:50...the oral diet of pigs. In contrast, cysteine is not included in any appreciable amounts...due to its instability ' in solution. Cysteine can replace part of the methionine requirement...
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Five Cysteine-Containing Compounds Have Antioxidative Activity in Balb/cA Mice1
Magazine article from: The Journal of Nutrition; 1/1/2004; ; 700+ words
; ABSTRACT Balb/cA mice were used to study the in vivo effect of N-acetyl cysteine, S-allyl cysteine, S-ethyl cysteine, S-methyl cysteine and S-propyl cysteine, all derived from garlic, on glutathione (GSH...
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Cysteine-containing garlic derivatives have antioxidative activity in mice.
Newspaper article from: Obesity, Fitness & Wellness Week; 3/13/2004; 700+ words
; ...net) -- Garlic-derived agents containing cysteine have significant antioxidant activity in mice...used to study the in vivo effect of N-acetyl cysteine, S-allyl cysteine, S-ethyl cysteine, S-methyl cysteine and...
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Cysteine-Cysteine Contact Preference Leads to Target-Focusing in Protein Folding
Magazine article from: Biophysical Journal; 8/1/2007; ; 700+ words
; ...when attraction among cysteines is nonspecific and comparable...expedites folding of cysteine-rich proteins as a...disulfide bonds orcysteine-cysteine interactions. Here...contact frequency among cysteines. We further extend...possibly benefit from cysteine-cysteine interactions...
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Cysteine sulfinic acid decarboxylas mRNA abundance decreases in rats fed a high-protein diet
Magazine article from: The Journal of Nutrition; 11/1/1998; ; 700+ words
; Cysteine Sulfinic Acid Decarboxylase mRNA Abundance...Kohlhepp ABSTRACT The partitioning of cysteine metabolism between sulfate and taurine...be regulated in part by the activity of cysteine sulfinic acid decarboxylase (CSAD...
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Five Cysteine-Containing Compounds Delay Diabetic Deterioration in Balb/cA Mice1
Magazine article from: The Journal of Nutrition; 12/1/2004; ; 700+ words
; ABSTRACT The effects of n-acetyl cysteine (NAC), s-allyl cysteine (SAC), s-ethyl cysteine, s-methyl cysteine and s-propyl cysteine (SPC) activity on Balb/cA mice against diabetic complications were examined. These complications...
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Effect of Five Cysteine-Containing Compounds on Three Lipogenic Enzymes in Balb/cA Mice Consuming a High Saturated Fat Diet
Magazine article from: Lipids; 9/1/2004; ; 700+ words
; ABSTRACT: The in vivo effects of N-acetyl cysteine (NAC), S-allyl cysteine, S-ethyl cysteine (SEC), S-methyl cysteine (SMC), and S-propyl cysteine (SPC) against hyperlipidemia...
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Targeting oxidized cysteine through diet could reduce inflammation and lower disease risk.
Newspaper article from: Heart Disease Weekly; 4/19/2009; 700+ words
; ...in critically ill patients by adding cysteine to intravenous or tube feeding (see...measure of oxidative stress in the blood: cysteine, an amino acid found in most proteins in the body. Cysteine can exist in two forms: oxidized and...
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Study of cysteine, cystine and methionine in normal and cataractous human lenses.(Articles)
Magazine article from: Indian Journal of Ophthalmology; 5/1/1983; ; 700+ words
; ...Kulshrestha, K. Khuteta, Y. Shukla Cysteine, Cystine and Methionine are sulphur...and pathological conditions of lens. Cysteine and Methionine form an integral part...the degradation of methionine by way of cysteine, cystine to either taurine or inorganic...
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cysteine
Book article from: The Columbia Encyclopedia, Sixth Edition
cysteine , organic compound, one of the 20 amino...hooves, and the keratin of the skin. Cysteine's importance is related to the presence...meat tenderizers. The thiol group of one cysteine residue is capable of combining with the...
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amino acids
Book article from: A Dictionary of Food and Nutrition
...arginine, aspartic acid, asparagine, cysteine, glutamic acid, glutamine, glycine...the body from essential amino acids: cysteine (and cystine) from methionine, and...vegetable proteins by the sum of methionine + cysteine (the sulphur amino acids ). In whole...
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homocystinuria
Book article from: A Dictionary of Food and Nutrition
...metabolism of the amino acid methionine and its conversion to cysteine, characterized by excretion of homocysteine and its derivatives...either by feeding a diet low in methionine and supplemented with cysteine or, in some cases by administration of high intakes of vitamin...
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methionine
Book article from: A Dictionary of Food and Nutrition
methionine An essential amino acid ; one of the three containing sulphur; cystine and cysteine are the other two. Cystine and cysteine are not essential, but can only be made from methionine, and therefore the requirement for methionine...
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cystine
Book article from: A Dictionary of Biology
...from the oxidation reaction between the sulphydryl (–SH) groups of two cysteine molecules (see amino acid ). This often occurs between adjacent cysteine residues in polypeptides. The resultant disulphide bridges (–S...
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