Skip to main content
Select Source:

Glycoprotein

Glycoprotein


Glycoproteins are proteins that contain covalently attached sugar residues. The hydrophilic and polar characteristics of sugars may dramatically change the chemical characteristics of the protein to which they are attached. The addition of sugars is often required for a glycoprotein to function properly and reach its ultimate destination in the cell or organism. Glycoproteins are frequently present at the surface of cells where they function as membrane proteins or as part of the extracellular matrix. These cell surface glycoproteins play a critical role in cellcell interactions and the mechanisms of infection by bacteria and viruses.

There are three types of glycoproteins based on their structure and the mechanism of synthesis: N-linked glycoproteins, O-linked glycoproteins, and nonenzymatic glycosylated glycoproteins.

N-linked glycoproteins are synthesized and modified within two membrane-bound organelles in the cell, the rough endoplasmic reticulum and the Golgi apparatus. The protein component of the glycoprotein is assembled on the surface of the rough endoplasmic reticulum by the sequential addition of amino acids, creating a linear polymer of amino acids called a polypeptide . Twenty different amino acids can be used for the synthesis of polypeptides. The specific order of the amino acids in the polypeptide is critical to its function and is referred to as the amino acid sequence. One of the twenty amino acids used for the synthesis of polypeptides, asparagine (C4H8N2O3), is essential for the synthesis of N-linked glycoproteins.

N-linked glycoproteins have carbohydrates attached to the R side chain of asparagine residues within a polypeptide. The carbohydrate is always located in amino acid sequences, where the asparagine is followed by some other amino acid and then a serine or threonine residue (-Asn-Xaa-Ser/Thr). Carbohydrate is not attached to the polypeptide one sugar at a time. Rather, a large preformed carbohydrate containing fourteen or more sugar residues is attached to the asparagine as the protein is being translated in the rough endoplasmic reticulum. The carbohydrate on the glycoprotein is then modified by enzymes that remove some sugars and attach others as the newly formed glycoprotein moves from the rough endoplasmic reticulum to the Golgi apparatus and other locations in the cell. Many N-linked glycoproteins eventually become part of the cell membrane or are secreted by the cell.

O-linked glycoproteins are usually synthesized by the addition of sugar residues to the hydroxyl side chain of serine or threonine residues in polypeptides in the Golgi apparatus. Unlike N-linked glycoproteins, O-linked glycoproteins are synthesized by the addition of a single sugar residue at a time. Many O-linked glycoproteins are secreted by the cell to become a part of the extracellular matrix that surrounds it.

Nonenzymatic glycosylation or glycation creates glycoproteins by the chemical addition of sugars to polypeptides. Since this type of glycosylation is nonenzymatic, the factors that control glycosylation are simply time and the concentration of sugar. Older proteins are more glycosylated, and people with higher circulating levels of glucose experience higher levels of nonenzymatic glycosylation. This is the basis of the glycosylated hemoglobin A1c diagnostic test used for the monitoring and long-term maintenance of blood sugar levels in diabetics.

see also Concentration Gradient; Proteins.

Robert Noiva

Bibliography

Berg, Jeremy M.; Tymoczko, John L.; and Stryer, Lubert (2002). Biochemistry, 5th edition. New York: W. H. Freeman.

Voet, Donald; Voet, Judith G.; and Pratt, Charlotte W. (2002). Fundamentals of Biochemistry, updated edition. New York: Wiley.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"Glycoprotein." Chemistry: Foundations and Applications. . Encyclopedia.com. 13 Dec. 2017 <http://www.encyclopedia.com>.

"Glycoprotein." Chemistry: Foundations and Applications. . Encyclopedia.com. (December 13, 2017). http://www.encyclopedia.com/science/news-wires-white-papers-and-books/glycoprotein

"Glycoprotein." Chemistry: Foundations and Applications. . Retrieved December 13, 2017 from Encyclopedia.com: http://www.encyclopedia.com/science/news-wires-white-papers-and-books/glycoprotein

glycoprotein

glycoprotein (glī´kōprō´tēn), organic compound composed of both a protein and a carbohydrate joined together in covalent chemical linkage. These structures occur in many life forms; they are prevalent and important in mammalian tissues. The attached carbohydrate may have several effects: it may help the protein to fold in the proper geometry, stabilize the protein, affect physical properties such as solubility or viscosity, helps it to orient correctly in a membrane, or make it recognizable to another biochemical or cell (see immunity). Many proteins released by cells to the blood and other fluids are glycoproteins. One set of glycoproteins also carry the blood group determinants. The carbohydrate portion of a glycoprotein is usually a small sugar or no more than 8 to 10 individual monosaccharide units. Combinations of up to seven of the many different sugar molecules known to occur in nature comprise the saccharide portions of mammalian glycoproteins: glucose, glucosamine, galactose, galactosamine, mannose, fucose, and sialic acid (a derivative of glucosamine). The linkage between the oligosaccharide and the protein occurs by formation of a chemical bond to only one of four protein amino acids: asparagine, hydroxylysine, serine, or threonine. Solutions of glycoproteins usually exhibit high viscosity, an observation explaining the highly viscous character of egg white, which is composed largely of the glycoprotein ovalbumin. Salivary mucus contains the glycoprotein called mucin. Among other glycoproteins, one particularly interesting example is isolated from certain antarctic fishes who survive near-freezing water temperatures as a result of freezing-point depression of their blood serum by a globular glycoprotein. This molecule is a remarkably effective freezing point depressant.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"glycoprotein." The Columbia Encyclopedia, 6th ed.. . Encyclopedia.com. 13 Dec. 2017 <http://www.encyclopedia.com>.

"glycoprotein." The Columbia Encyclopedia, 6th ed.. . Encyclopedia.com. (December 13, 2017). http://www.encyclopedia.com/reference/encyclopedias-almanacs-transcripts-and-maps/glycoprotein

"glycoprotein." The Columbia Encyclopedia, 6th ed.. . Retrieved December 13, 2017 from Encyclopedia.com: http://www.encyclopedia.com/reference/encyclopedias-almanacs-transcripts-and-maps/glycoprotein

glycoprotein

glycoprotein A carbohydrate linked covalently to a protein. Formed in the Golgi apparatus in the process of glycosylation, glycoproteins are important components of plasma membranes, in which they extend throughout the lipid bilayer. They are also constituents of body fluids, such as mucus, that are involved in lubrication. Many of the hormone receptors on the surfaces of cells have been identified as glycoproteins. Glycoproteins produced by viruses attach themselves to the surface of the host cell, where they act as markers for the receptors of leucocytes. Viral glycoproteins can also act as target molecules and help viruses to detect certain types of host cell; for example, a glycoprotein on the surface of HIV enables the virus to find and infect white blood cells.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"glycoprotein." A Dictionary of Biology. . Encyclopedia.com. 13 Dec. 2017 <http://www.encyclopedia.com>.

"glycoprotein." A Dictionary of Biology. . Encyclopedia.com. (December 13, 2017). http://www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein-1

"glycoprotein." A Dictionary of Biology. . Retrieved December 13, 2017 from Encyclopedia.com: http://www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein-1

glycoproteins

glycoproteins Proteins conjugated with carbohydrates such as uronic acids, polymerized glucosamine‐mannose, etc., including mucins and mucoids; found in the vitreous humour of the eye, cornea, cartilage, and gastric mucosa. See also mucoproteins.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"glycoproteins." A Dictionary of Food and Nutrition. . Encyclopedia.com. 13 Dec. 2017 <http://www.encyclopedia.com>.

"glycoproteins." A Dictionary of Food and Nutrition. . Encyclopedia.com. (December 13, 2017). http://www.encyclopedia.com/education/dictionaries-thesauruses-pictures-and-press-releases/glycoproteins

"glycoproteins." A Dictionary of Food and Nutrition. . Retrieved December 13, 2017 from Encyclopedia.com: http://www.encyclopedia.com/education/dictionaries-thesauruses-pictures-and-press-releases/glycoproteins

glycoprotein

gly·co·pro·tein / ˌglīkōˈprōtēn/ • n. Biochem. any of a class of proteins that have carbohydrate groups attached to the polypeptide chain. Also called glycopeptide.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"glycoprotein." The Oxford Pocket Dictionary of Current English. . Encyclopedia.com. 13 Dec. 2017 <http://www.encyclopedia.com>.

"glycoprotein." The Oxford Pocket Dictionary of Current English. . Encyclopedia.com. (December 13, 2017). http://www.encyclopedia.com/humanities/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein

"glycoprotein." The Oxford Pocket Dictionary of Current English. . Retrieved December 13, 2017 from Encyclopedia.com: http://www.encyclopedia.com/humanities/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein

glycoprotein

glycoprotein (gly-koh-proh-teen) n. one of a group of compounds consisting of a protein combined with a carbohydrate (such as galactose or mannose). Examples of glycoproteins are certain enzymes, hormones, and antigens.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"glycoprotein." A Dictionary of Nursing. . Encyclopedia.com. 13 Dec. 2017 <http://www.encyclopedia.com>.

"glycoprotein." A Dictionary of Nursing. . Encyclopedia.com. (December 13, 2017). http://www.encyclopedia.com/caregiving/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein

"glycoprotein." A Dictionary of Nursing. . Retrieved December 13, 2017 from Encyclopedia.com: http://www.encyclopedia.com/caregiving/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein

mucoproteins

mucoproteins Glycoproteins containing a sugar, usually chondroitin sulphate, combined with amino acids or peptides; occur in mucin.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"mucoproteins." A Dictionary of Food and Nutrition. . Encyclopedia.com. 13 Dec. 2017 <http://www.encyclopedia.com>.

"mucoproteins." A Dictionary of Food and Nutrition. . Encyclopedia.com. (December 13, 2017). http://www.encyclopedia.com/education/dictionaries-thesauruses-pictures-and-press-releases/mucoproteins

"mucoproteins." A Dictionary of Food and Nutrition. . Retrieved December 13, 2017 from Encyclopedia.com: http://www.encyclopedia.com/education/dictionaries-thesauruses-pictures-and-press-releases/mucoproteins

glycoprotein

glycoprotein A conjugated protein that consists of a carbohydrate covalently linked to a protein (e.g. mucins and mucoids).

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"glycoprotein." A Dictionary of Zoology. . Encyclopedia.com. 13 Dec. 2017 <http://www.encyclopedia.com>.

"glycoprotein." A Dictionary of Zoology. . Encyclopedia.com. (December 13, 2017). http://www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein-0

"glycoprotein." A Dictionary of Zoology. . Retrieved December 13, 2017 from Encyclopedia.com: http://www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein-0

glycoprotein

glycoprotein A conjugated protein that consists of a carbohydrate covalently linked to a protein.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"glycoprotein." A Dictionary of Plant Sciences. . Encyclopedia.com. 13 Dec. 2017 <http://www.encyclopedia.com>.

"glycoprotein." A Dictionary of Plant Sciences. . Encyclopedia.com. (December 13, 2017). http://www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein

"glycoprotein." A Dictionary of Plant Sciences. . Retrieved December 13, 2017 from Encyclopedia.com: http://www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/glycoprotein