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fatal familial insomnia

A Dictionary of Nursing | 2008 | © A Dictionary of Nursing 2008, originally published by Oxford University Press 2008. (Hide copyright information) Copyright

fatal familial insomnia (fay-t'l) n. an autosomal dominant disorder due to a mutation in the gene for the prion protein (PrP): it is an example of a spongiform encephalopathy. Patients present with intractable progressive insomnia, disturbances of the autonomic nervous system, and eventually dementia.

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