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glycoprotein
glycoprotein
glycoprotein A carbohydrate linked covalently to a protein. Formed in the Golgi apparatus in the process of
glycosylation, glycoproteins are important components of plasma membranes, in which they extend throughout the
lipid bilayer. They are also constituents of body fluids, such as mucus, that are involved in lubrication. Many of the hormone receptors on the surfaces of cells have been identified as glycoproteins. Glycoproteins produced by viruses attach themselves to the surface of the host cell, where they act as markers for the receptors of leucocytes. Viral glycoproteins can also act as target molecules and help viruses to detect certain types of host cell; for example, a glycoprotein on the surface of
HIV enables the virus to find and infect white blood cells.
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Influence of the heterogeneity of P-glycoprotein expression on technetium-99m-MIBI uptake in breast cancer
Magazine article from: The Journal of Nuclear Medicine; 6/1/1998; ; 700+ words
; ...MIBI) and the heterogeneity of p-glycoprotein expression in tumor tissues. Methods...sections of the same tumor using a p-glycoprotein-specific monoclonal antibody, JSB...the level and heterogeneity of p-glycoprotein expression determined by immunohistochemical...
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Clinical validation of the influence of P-Glycoprotein on Technetium-99m-Sestamibi uptake in malignant tumors
Magazine article from: The Journal of Nuclear Medicine; 7/1/1997; ; 700+ words
; ...sestamibi and the expression of p-glycoprotein in tumor tissues. Methods...against the internal epitope of p-glycoprotein. Tumor-to-background ratios...correlated with the level of p-glycoprotein expression determined by immunohistochemical...
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Interaction of Transported Drugs with the Lipid Bilayer and P-Glycoprotein through a Solvation Exchange Mechanism
Magazine article from: Biophysical Journal; 6/1/2006; ; 700+ words
; ...substrate specificity of human P-glycoprotein (ABCB1) is an essential feature of...resistance. Transport substrates of P-glycoprotein are mostly hydrophobic and many of...the energy of ATP hydrolysis, P-glycoprotein is thought to take up substrates from...
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Theoretical aspects of p-glycoprotein mediated drug efflux on the distribution volume of anaesthetic-related drugs in the brain
Magazine article from: Anaesthesia and Intensive Care; 4/1/2002; ; 700+ words
; SUMMARY P-glycoprotein in the membranes of endothelial...The theoretical effect of P-glycoprotein mediated drug efflux on the cerebral...governed by the ratio of the P-glycoprotein drug clearance from the membrane...
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P-glycoprotein in drug resistance analyzed, cholesterol-induced change revealed.
Newspaper article from: World Disease Weekly; 12/28/2004; 700+ words
; ...cellular cholesterol alters P-glycoprotein activity in multidrug-resistant...The drug transporter P-glycoprotein (ABCB1) plays an important...multidrug resistance (MDR). P-glycoprotein is localized in the plasma membrane...
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Synthesis and Evaluation of Dopamine D^sub 3^ Receptor Antagonist ^sup 11^C-GR218231 as PET Tracer for P-Glycoprotein
Magazine article from: The Journal of Nuclear Medicine; 8/1/2005; ; 700+ words
; ...GR218231 could be a substrate of the P-glycoprotein efflux pump. P-glycoprotein protects the brain against toxic substances...applied as a PET tracer for monitoring P-glycoprotein activity in the blood-brain barrier. Such...
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Dietary spermidine and spermine participate in the maturation of galactosyltransferase activity and glycoprotein galactosylation in rat small intestine
Magazine article from: The Journal of Nutrition; 7/1/2001; ; 700+ words
; ...maturation of intestinal glycoprotein galactosylation during...biosynthesis of mucins and of glycoproteins in the brush border...border membranes are glycoproteins (lactase, sucrase...Changes in intestinal glycoprotein glycosylation have...brush border membrane glycoproteins (5-7) and the...
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14-3-3 Proteins Are Constituents of the Insoluble Glycoprotein Framework of the Chlamydomonas Cell Wall
Magazine article from: Plant Cell; 6/1/2003; ; 700+ words
; ...predominantly of Hyp-rich glycoproteins, which also occur...polypeptides, the insoluble glycoprotein framework of the Chlamydomonas...2001). Hyp-rich glycoproteins are the predominant...insoluble, Hyp-rich glycoprotein framework and several...Hyp-containing glycoproteins (Roberts, 1974...
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Test for salivary glycoproteins may soon predict caries risk.(Infectious Diseases)
Magazine article from: Internal Medicine News; 6/15/2005; ; 700+ words
; ...galactose as part of the glycoproteins in their pellicle and saliva...researchers tested for eight glycoproteins in 21 different people...risk can be predicted with glycoprotein testing alone. For instance...had cavities had common glycoproteins (risk level 1), but those...
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Test may determine caries risk per person; combinations of glycoproteins present naturally in a person's mouth appear related to cavity risk.(Clinical Rounds)
Magazine article from: Pediatric News; 8/1/2005; ; 700+ words
; ...galactose as part of the glycoproteins in their pellicle and saliva...researchers tested for eight glycoproteins in 21 different people...risk can be predicted with glycoprotein testing alone. For instance...had cavities had common glycoproteins (risk level 1), but those...
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Glycoprotein
Book article from: Chemistry: Foundations and Applications
Glycoprotein Glycoproteins are proteins...required for a glycoprotein to function...or organism. Glycoproteins are frequently...newly formed glycoprotein moves from the...Many N-linked glycoproteins eventually become...
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glycoprotein
Book article from: The Columbia Encyclopedia, Sixth Edition
...One set of glycoproteins also carry the...portion of a glycoprotein is usually a...largely of the glycoprotein ovalbumin. Salivary...contains the glycoprotein called mucin. Among other glycoproteins, one particularly...
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glycoproteins
Book article from: A Dictionary of Food and Nutrition
glycoproteins Proteins conjugated with carbohydrates such as uronic acids, polymerized glucosamine‐mannose, etc., including mucins and mucoids; found in the vitreous humour of the eye, cornea, cartilage, and gastric mucosa. See also mucoproteins .
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Hemagglutinin (HA) and Neuraminidase(NA)
Book article from: World of Microbiology and Immunology
...designated as NA) are glycoproteins. Hemagglutinin and...viral contents. A glycoprotein is a protein that...and neuraminidase glycoproteins are important in the...neuraminyl hydrolase. The glycoprotein compound is an enzyme...sugars and from other glycoproteins. The disruption of...
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Human Immunodeficiency Virus (HIV)
Book article from: World of Microbiology and Immunology
...enclosed in an outer lipid envelope. A viral glycoprotein (gp120) is displayed on the surface of...while the env gene codes for the envelope glycoprotein including the outer envelope glycoprotein (gp 120) and the transmembrane glycoprotein...
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