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gene
gene
gene A unit of heredity composed of DNA. In classical genetics (see
Mendelism;
Mendel's laws) a gene is visualized as a discrete particle, forming part of a
chromosome, that determines a particular characteristic. It can exist in different forms called
alleles, which determine which aspect of the characteristic is shown (e.g. tallness or shortness for the characteristic of height).
A gene occupies a specific position (
locus) on a chromosome. In view of the discoveries of molecular genetics, it may be defined as the sequence of nucleotides of DNA (or RNA) concerned with a specific function, such as the synthesis of a single polypeptide chain or of a messenger RNA molecule, corresponding to a particular sequence of the
genetic code. One or more of these
structural genes, coding for protein, may be associated with other genes controlling their expression (see
operon). See also
cistron.
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Gene therapy: science fiction or reality?
Magazine article from: Southern Medical Journal; 1/1/2007; ; 700+ words
; ...in the discovery of genes associated with disease pathologies, gene therapy strategies...mechanism, suicide gene therapy, utilizes...known as "suicide genes," which selectively...variations of potential gene therapy vectors that...employed to deliver these genes, each having their...
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Gene and pathway identification with L .sub. p penalized Bayesian logistic regression.(Methodology article)(Report)
Magazine article from: BMC Bioinformatics; 10/3/2008; ; 700+ words
; ...underlying causes of the cancer. In gene selection, when genes share the same biological pathway...characteristic of the regulatory genes is that their gene expression changes may be low...hunt the upstream regulatory genes in gene selection and pathway discovery...
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Genes replicate like the hairs of the Monkey King
Newspaper article from: China Daily; 4/20/2004; ; 700+ words
; ...through a process known as gene fission. The new genes originate by copying their...of the major ways for genes to evolve. Their gene genesis mechanism also...identified scores of such genes, including the first RNA gene discovered, the sphinx...
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Gene therapy in dermatology.(Clinical Signs)
Magazine article from: Indian Journal of Dermatology; 7/1/2006; ; 700+ words
; ...Introduction of a normal gene into cells or tissues which have defective genes for the treatment of genetic disease is called gene therapy. However gene...Although delivery of the genes into the cells requires...are by definition not gene therapy. The basic technique...
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Gene Dosage and Gene Duplicability
Magazine article from: Genetics; 8/1/2008; ; 700+ words
; ...dosage (i.e., the gene dosage hypothesis...because haploinsufficient genes were reported to have...fixation of duplication genes. GENE duplication is the...for a haplosufficient gene. Consequently, haploinsufficient genes should have higher...
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Gene traps: Tools for plant develoopment and genomics
Magazine article from: Plant Cell; 7/1/2000; ; 700+ words
; ...the corresponding gene. Not all genes, however, can be...Analysis of systematic gene knockouts has revealed...percentage of yeast genes have no obvious phenotype...with microarray and gene chip technologies...expression profiles of many genes to be analyzed (Richmond...
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Genes encoding pentatricopeptide repeat (PPR) proteins are not conserved in location in plant genomes and may be subject to diversifying selection.(Research article)(Clinical report)
Magazine article from: BMC Genomics; 5/23/2007; ; 700+ words
; ...complement of PPR genes within plant genomes...have occurred through gene duplication. In Arabidopsis...tandem and segmental gene duplication, creating clusters of identical genes that diverge over...in a cluster of PPR genes at a genomic site where no corresponding PPR gene is found ...
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GENE LOGIC Enters Genomics Alliance with Japan Tobacco for Drug Discovery in Renal Disease and Other Indications.
Business Wire; 9/9/1997; 700+ words
; ...analyze gene expression and gene regulation in both human...disease models to identify genes related to the onset and...Topography(TM) tool, GENE LOGIC is able to produce...quantitative picture of all the genes used in a human cell...accelerated discovery process, GENE LOGIC creates ...
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Gene selection for classification of microarray data based on the Bayes error.(Methodology article)
Magazine article from: BMC Bioinformatics; 10/3/2007; ; 700+ words
; ...have been developed for gene selection to extract relevant genes from thousands of genes...correlations with other genes. Although such gene ranking criteria are simple...inclusion of redundant genes in selected gene set used for classification...
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Gene Logic's Gene Expression Databases Spur Major Drug Discovery Efforts - 24 Programs Underway Across Multiple Disease Areas -.
PR Newswire; 2/11/2000; 700+ words
; ...these programs is based on genes discovered by Gene Logic to be associated with...these disease-associated genes using Gene Logic's gene expression...functions of genes. Since genes direct all biological processes, gene expression information is...
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Gene Therapy
Encyclopedia entry from: The Gale Encyclopedia of Science
...treat an individual that has an abnormal gene. Germline gene therapy inserts genes into reproductive cells (the egg or the...defined as a segment of the chromosome. The gene, or combination of genes formed by these base pairs ultimately direct...
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Gene Expression: Overview of Control
Book article from: Genetics
Gene Expression: Overview...an organism contain genes that encode all of...problems of control of gene expression. While the genes whose final products...Genetic Information from Genes to Proteins Cells can regulate gene expression at every...
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Gene Families
Book article from: Genetics
...years. The members of a gene family may include expressed genes as well as nonexpressed...preserved gene order within a gene family. These genes play a role in the spatial...arrangements. In some gene families, related genes have stayed together over...
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Overlapping Genes
Book article from: Genetics
...linear fashion, one gene after another. The...afforded by overlapping genes extends to the human...undiscovered overlapping genes, although more may...exons in a single gene. In algae called...neutral mutations in a gene (mutations that have...unlikely with overlapping genes, because ...
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Gene
Book article from: World of Forensic Science
...unit of heritable genetic information (the gene), and can use genes to single out a person. A gene is an individual element of an organism...biochemical structure or a metabolic process. Genes are segments of nucleic acid, consisting...
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