La Guaira
La Guaira , city (1990 pop. 23,831), capital of Vargas state, N Venezuela, on the Caribbean Sea NW of Caracas. It is the principal international port of Venezuela; cacao, coffee, and tobacco are the chief exports. La Guaira is also a seaside resort. Founded in the 16th cent. as an outlet for Caracas, the city was sacked by English pirates in 1743. During the war for independence (19th cent.), La Guaira's dungeons held many noted political prisoners. The international airport for Caracas is located in nearby Maiquetía.
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Ligand Pharmaceuticals and the SALK Institute Enter Settlement Agreement and Mutual Release of All Claims.
Business Wire; 9/5/2008; 700+ words
; SAN DIEGO -- Ligand Pharmaceuticals Incorporated (NASDAQ...ongoing arbitration between the parties. Ligand and SALK agreed to terminate their January...conveyance of rights to any third party. Ligand does not believe that it requires a license...
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Ligand and Private Investors Complete Second Investment in X-Ceptor.
Business Wire; 10/7/1999; 700+ words
; ...BW HealthWire)--Oct. 7, 1999-- Ligand Pharmaceuticals Incorporated (Nasdaq...the field of orphan nuclear receptors. Ligand invested $3.2 million in cash and other...25 million. At the second closing, Ligand also issued to X-Ceptor investors...
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LIGAND ELECTS TO RECEIVE MILESTONE PAYMENTS FROM PFIZER IN LIGAND COMMON STOCK; LIGAND COULD RETIRE OVER 101,000 SHARES
PR Newswire; 5/7/1996; 700+ words
; SAN DIEGO, May 7 /PRNewswire/ -- Ligand Pharmaceuticals Inc. (Nasdaq: LGND...from Pfizer Inc (NYSE: PFE) paid in Ligand stock, currently held by Pfizer. Under the terms of a recently settled lawsuit, Ligand has been deemed to have earned a second...
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Ligand Exercises First Option to Buy Down ONTAK Royalties.
Business Wire; 1/7/2005; 700+ words
; SAN DIEGO -- Ligand Pharmaceuticals (NASDAQ:LGND) announced...royalties payable to Lilly on sales of Ligand's marketed cancer drug ONTAK(R) (denileukin diftitox) in the United States. Ligand recorded sales of $34.3 million for...
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Ligand Pays Elan Milestone for Morphelan--TM-- NDA Submission.
Business Wire; 6/8/2000; 700+ words
; ...BW HealthWire)--June 8, 2000 Ligand Pharmaceuticals Incorporated (Nasdaq...plc (NYSE:ELN) 367,183 shares of Ligand common stock in connection with Elan...10.89, the average closing price of Ligand common stock for the five trading days...
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Ligand Restructures AVINZA License and Supply Agreement.
Business Wire; 11/12/2002; 700+ words
; ...Exchange for $100 Million Up-Front Payment Ligand to Purchase and Retire 2.2 Million Ligand Shares Held by Elan; Elan Agrees to 6-Month Lock-Up on 11.8 Million Remaining Shares Ligand Pharmaceuticals (Nasdaq: LGND) announced...
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Ligand Exercises Final Option to Buy Down ONTAK Royalties.
Business Wire; 4/7/2005; 700+ words
; SAN DIEGO -- Ligand Pharmaceuticals Incorporated (NASDAQ...royalties payable to Lilly on sales of Ligand's marketed cancer drug ONTAK(R) (denileukin diftitox) in the United States. Ligand will make a one-time cash payment of...
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Ligand Terminates Long-Term Lease Obligation.
Business Wire; 8/10/2009; 700+ words
; ...Long-term Overhead Costs SAN DIEGO -- Ligand Pharmaceuticals Incorporated (NASDAQ...Diego. Under the terms of the agreement, Ligand will pay a termination fee of $14.3...million in April 2011. In addition, Ligand entered into a new lease for a period...
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Ligand Issues $40.0 Million Zero Coupon Convertible Notes to Elan Corporation, plc.
Business Wire; 7/16/1999; 700+ words
; ...BW HealthWire)--July 15, 1999-- Ligand Pharmaceuticals Incorporated (Nasdaq...Agreement). The Notes are convertible into Ligand common stock at $14.00 per share...11.00. Under the Elan Agreement, Ligand may use the proceeds of the Note issuance...
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Ligand and Elan Launch Strategic Alliance; Provides Ligand With Up To $130 Million in Funding, Rights to Morphelan for HIV and Oncology Markets.
Business Wire; 11/10/1998; 700+ words
; ...BW HealthWire)--Nov. 9, 1998--Ligand Pharmaceuticals Incorporated (Nasdaq:LGND...which Elan agreed to purchase $20 million of Ligand Common Stock and to purchase from Ligand up to $110 million in issue price of Zero Coupon...
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Ligand Pharmaceuticals Incorporated
Book article from: International Directory of Company Histories
Ligand Pharmaceuticals Incorporated 10275 Science...Operating out of San Diego, California, Ligand Pharmaceuticals Incorporated discovers...cardiovascular diseases, and inflammatory diseases. Ligand ’ s drug development program relies...
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Ligand
Encyclopedia entry from: The Gale Encyclopedia of Science
Ligand In inorganic chemistry, ligands are molecules...are bonded to metal atoms or ions. The ligand changes the metal ’ s ability...with it (Figure 1). Thus, the metal and ligand are joined by a covalent bond, consisting...
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ligand-gated ion channel
Book article from: A Dictionary of Biology
ligand-gated ion channel A type of ion channel that opens when a signal molecule (ligand) binds to an extracellular receptor region of...of the muscle cell membrane. Other types of ligand-gated ion channels are found at synapses and...
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ligand
Book article from: A Dictionary of Zoology
ligand An atom, ion, or molecule that acts as the electron-donor partner in one or more co-ordination bonds. A hetero-cyclic ring is formed if the ligand is an organic compound, and the product is termed a chelate.
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Coordination Compound
Encyclopedia entry from: The Gale Encyclopedia of Science
...are shared between transition metal and ligand. But in a coordination compound, both electrons come from a pair found on the ligand (Figure 1). Table 1. Typical Transition...Typical Ligands, L Name as Ligand Ordinary name Electrically :NH ammine...
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