Biochemistry

The Columbia Encyclopedia,... A Dictionary of Nursing A Dictionary of Biology A Dictionary of Plant Sciences Further reading

uracil

The Columbia Encyclopedia, 6th ed. | 2008 | Copyright

uracil , organic base of the pyrimidine family. It was isolated from herring sperm and also produced in a laboratory in 1900-1901. When combined with the sugar ribose in a glycosidic linkage, uracil forms a derivative called uridine (a nucleoside), which in turn can be phosphorylated with from one to three phosphoric acid groups, yielding respectively the three nucleotides UMP (uridine monophosphate), UDP (uridine diphosphate), and UTP (uridine triphosphate). The analogous nucleosides and nucleotides formed from uridine and deoxyribose occur only very rarely in living systems; such is not the case with the other pyrimidines. The nucleotide derivatives of uracil perform important functions in cellular metabolism, particularly in carbohydrate metabolism; UTP acts as a coenzyme in the biosynthesis of sucrose in plants, lactose and glycogen in mammals, and chitin in insects. It can also readily donate one of its phosphate groups to adenosine diphosphate (ADP) to form adenosine triphosphate (ATP), an extremely important intermediate in the transfer of chemical energy in living cells. Since the uracil nucleotides contain only ribose and not deoxyribose, UTP is the source of uridine only in ribonucleic acid (RNA); there is no uridine in deoxyribonucleic acid (DNA). Its involvement in the biosynthesis of RNA demonstrates that uracil is important in the translation of genetic information (see nucleic acid ). A few laboratory derivatives of uracil have been designed as experimental antimetabolites (see metabolite ) for use in cancer chemotherapy.

Cite this article
Pick a style below, and copy the text for your bibliography.

MLA
Chicago
APA

"uracil." The Columbia Encyclopedia, 6th ed.. 2008. Encyclopedia.com. 11 Feb. 2012 <http://www.encyclopedia.com>.

"uracil." The Columbia Encyclopedia, 6th ed.. 2008. Encyclopedia.com. (February 11, 2012). http://www.encyclopedia.com/doc/1E1-uracil.html

"uracil." The Columbia Encyclopedia, 6th ed.. 2008. Retrieved February 11, 2012 from Encyclopedia.com: http://www.encyclopedia.com/doc/1E1-uracil.html

Learn more about citation styles

uracil

A Dictionary of Nursing | 2008 | Copyright

uracil (yoor-ă-sil) n. one of the nitrogen-containing bases (see pyrimidine) occurring in the nucleic acid RNA.

Cite this article
Pick a style below, and copy the text for your bibliography.

MLA
Chicago
APA

"uracil." A Dictionary of Nursing. 2008. Encyclopedia.com. 11 Feb. 2012 <http://www.encyclopedia.com>.

"uracil." A Dictionary of Nursing. 2008. Encyclopedia.com. (February 11, 2012). http://www.encyclopedia.com/doc/1O62-uracil.html

"uracil." A Dictionary of Nursing. 2008. Retrieved February 11, 2012 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O62-uracil.html

Learn more about citation styles

uracil

A Dictionary of Biology | 2004 | Copyright

uracil A pyrimidine derivative and one of the major component bases of nucleotides and the nucleic acid RNA.

Cite this article
Pick a style below, and copy the text for your bibliography.

MLA
Chicago
APA

"uracil." A Dictionary of Biology. 2004. Encyclopedia.com. 11 Feb. 2012 <http://www.encyclopedia.com>.

"uracil." A Dictionary of Biology. 2004. Encyclopedia.com. (February 11, 2012). http://www.encyclopedia.com/doc/1O6-uracil.html

"uracil." A Dictionary of Biology. 2004. Retrieved February 11, 2012 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O6-uracil.html

Learn more about citation styles

uracil

A Dictionary of Plant Sciences | 1998 | | Copyright

uracil A pyrimidine base that occurs in RNA.

Cite this article
Pick a style below, and copy the text for your bibliography.

MLA
Chicago
APA

MICHAEL ALLABY. "uracil." A Dictionary of Plant Sciences. 1998. Encyclopedia.com. 11 Feb. 2012 <http://www.encyclopedia.com>.

MICHAEL ALLABY. "uracil." A Dictionary of Plant Sciences. 1998. Encyclopedia.com. (February 11, 2012). http://www.encyclopedia.com/doc/1O7-uracil.html

MICHAEL ALLABY. "uracil." A Dictionary of Plant Sciences. 1998. Retrieved February 11, 2012 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O7-uracil.html

Learn more about citation styles

uracil

A Dictionary of Zoology | 1999 | | Copyright

uracil A pyrimidine base that occurs in RNA.

Cite this article
Pick a style below, and copy the text for your bibliography.

MLA
Chicago
APA

MICHAEL ALLABY. "uracil." A Dictionary of Zoology. 1999. Encyclopedia.com. 11 Feb. 2012 <http://www.encyclopedia.com>.

MICHAEL ALLABY. "uracil." A Dictionary of Zoology. 1999. Encyclopedia.com. (February 11, 2012). http://www.encyclopedia.com/doc/1O8-uracil.html

MICHAEL ALLABY. "uracil." A Dictionary of Zoology. 1999. Retrieved February 11, 2012 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O8-uracil.html

Learn more about citation styles

Free newspaper and magazine articles

	Uracil/ftorafur/leucovorin combined with irinotecan (TEGAFIRI) or oxaliplatin... Magazine article from: Advances in Gastrointestinal Cancer; 6/1/2007
	Folate deficiency in vitro induces uracil misincorporation and DNA... Magazine article from: Alternative Medicine Review; 4/1/2001
	Early earth may have had two key RNA bases. (pyrimidine bases of cytosine and... Magazine article from: Science News; 7/1/1995