protease inhibitor

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protease inhibitor

The Columbia Encyclopedia, Sixth Edition | 2008 | The Columbia Encyclopedia, Sixth Edition. Copyright 2008 Columbia University Press. (Hide copyright information) Copyright

protease inhibitor , any of a class of drugs that interfere with replication of the AIDS virus ( HIV ), by blocking an enzyme (protease) necessary in the late stages of its reproduction. Clinical trials of the protease inhibitor indinavir have shown it to be especially beneficial in combination with the anti-HIV drugs AZT and 3TC, which act by blocking a different enzyme, reverse transcriptase. Saquinavir, the first member of the class to be marketed, was approved for use in 1995 by the Food and Drug Administration.

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protease inhibitor

A Dictionary of Nursing | 2008 | © A Dictionary of Nursing 2008, originally published by Oxford University Press 2008. (Hide copyright information) Copyright

protease inhibitor n. one of a class of antiretroviral drugs used in the treatment of HIV infection and AIDS. They inhibit the action of protease produced by HIV, required by viral growth and replication. Protease inhibitors include atazanavir (Reyataz), indinavir (Crixivan), lopinavir (Kaletra), and tipranavir (Aptivus).
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Non-peptide protease inhibitors as vovel antiHIV agents.(Review Article)
Magazine article from: Indian Journal of Pharmaceutical Sciences; 9/1/2006; ; 700+ words ; ...Thus by inhibiting HIV-1 protease activity[5],[6...development of HIV protease inhibitors; while in clinical trials, existent HIV-1 protease inhibitors show promise in causing an...patients taking protease inhibitors alone. Failure of HIV-1 protease inhibitor ...
Clinical update; impact of HIV protease inhibitors on the treatment of HIV-infected tuberculosis patients with rifampin.(Notice To Readers)
Newspaper article from: Morbidity and Mortality Weekly Report; 10/25/1996; 700+ words ; ...products in the new protease inhibitor class of drugs...these protease inhibitors interact with...rifampin and protease inhibitors. Because of...prescribed protease inhibitor therapy. MANAGEMENT...therapy with a protease inhibitor. The duration...than ...
What you need to know about protease inhibitors: new class of drugs increases treatment options.
Newspaper article from: AIDS Alert; 4/1/1996; 700+ words ; ...class of drugs called protbase inhibitors is hitting the market. The...deciding whether to take a protease inhibitor, you should learn more about...Even if you are convinced protease inhibitors can give you the best outcome...
Cross-Tolerance Risk Depends On Protease Inhibitor.(Brief Article)
Newspaper article from: AIDS Weekly; 6/11/2001; 700+ words ; ...medical writer - Some protease inhibitors are much more likely...susceptibility to protease inhibitors in patients failing an initial protease inhibitor-containing regimen...study include: * Protease inhibitors have significantly...unsuccessful protease ...
Protease Inhibitors, Coronary Disease Possibly Linked.(Statistical Data Included)
Newspaper article from: AIDS Weekly; 11/22/1999; 700+ words ; ...suggest that HIV protease inhibitors in fact do more harm...term impact of HIV protease inhibitors. To that end, Stein...the effects of HIV protease inhibitors on patients...cross-reacting with proteases naturally generated...thinking is that HIV protease ...
Data Presented on Substitution of Efavirenz for Protease Inhibitor.(Sustiva substituted for protease inhibitor)
Newspaper article from: Biotech Week; 2/21/2001; ; 700+ words ; ...and substitute the protease inhibitor(s) with 600 mg...discontinued in the protease inhibitor-containing arm...replacement of protease inhibitors with Sustiva in combination...treated with protease inhibitor-containing regimens...
Data Presented on Substitution of Efavirenz for Protease Inhibitor.(for HIV treatment)
Newspaper article from: Virus Weekly; 2/20/2001; 700+ words ; ...and substitute the protease inhibitor(s) with 600 mg...discontinued in the protease inhibitor-containing arm...replacement of protease inhibitors with Sustiva in combination...treated with protease inhibitor-containing regimens...
Data Presented on Substitution of Efavirenz for Protease Inhibitor.(Brief Article)
Newspaper article from: AIDS Weekly; 2/19/2001; 700+ words ; ...and substitute the protease inhibitor(s) with 600 mg...discontinued in the protease inhibitor-containing arm...replacement of protease inhibitors with Sustiva in combination...treated with protease inhibitor-containing regimens...
KHEPRI PHARMACEUTICALS' PROTEASE INHIBITORS PREVENT ARTHRITIS-RELATED JOINT AND BONE DAMAGE IN RESEARCH STUDIES
PR Newswire; 8/18/1995; 700+ words ; ...excessive functioning of proteases, naturally occurring...natural equilibrium of protease activity present excellent...Mechanism-Based Cysteine Protease Inhibitors" appearing in this...same time, their (inhibitor) specificity and...discovered protein inhibitors as candidate ...
TB drugs interact adversely with protease inhibitors: HIV in blood increased in those with TB.
Newspaper article from: AIDS Alert; 10/1/1996; 700+ words ; ...the patients on protease inhibitors...likely scenario, as protease inhibitors become...interrupting protease inhibitor treatment could...strains resistant to protease inhibitors. For some HIV...interrupting protease inhibitor therapy will not...between ...

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