methotrexate

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methotrexate

methotrexate drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemia , psoriasis , and non-Hodgkin's lymphoma . By binding to an enzyme that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acids and therefore with tissue cell reproduction. Because of its immunosuppressive qualities, it is also used in the treatment of rheumatoid arthritis .

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methotrexate

A Dictionary of Nursing | 2008 | Â© A Dictionary of Nursing 2008, originally published by Oxford University Press 2008. (Hide copyright information) Copyright

methotrexate (meth-oh-treks-ayt) n. a drug that interferes with cell growth and is administered by mouth or injection to treat many types of cancer, including leukaemia in children and various solid tumours (see antimetabolite). It also affects the immune response and may be used in the treatment of rheumatoid arthritis and severe psoriasis.

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CMF

A Dictionary of Nursing | 2008 | Â© A Dictionary of Nursing 2008, originally published by Oxford University Press 2008. (Hide copyright information) Copyright

CMF n. cyclophosphamide, methotrexate, 5-fluorouracil: the combination of chemotherapy drugs used in standard treatment for breast cancer.

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Free newspaper and magazine articles

	Exposure of oncologic nurses to methotrexate in the treatment of osteosarcoma. Magazine article from: Archives of Environmental Health; 7/1/1996
	Study Showed Half of Patients Treated with Enbrel(R) (etanercept) Plus Methotrexate Can Achieve DAS Clinical Remission and 80 Percent Had No Progression of Joint Damage in Active Early Rheumatoid Arthritis.(Clinical report) Business Wire; 7/15/2008
	Pancytopenia after a single intradermal infiltration of methotrexate.(CASE REPORTS) Magazine article from: Journal of Drugs in Dermatology; 9/1/2005

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