estrogen

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estrogen

The Columbia Encyclopedia, Sixth Edition | 2008 | The Columbia Encyclopedia, Sixth Edition. Copyright 2008 Columbia University Press. (Hide copyright information) Copyright

estrogen , any one of a group of hormones synthesized by the reproductive organs and adrenal glands in females and, in lesser quantities, in males. The estrogens cause the thickening of the lining of the uterus and vagina in the early phase of the ovulatory, or menstrual, cycle (see menstruation ); in lower animals cyclical estrogen secretion also induces estrus, or "heat." The estrogens are also responsible for female secondary sex characteristics such as, in humans, pubic hair and breasts, and they affect other tissues including the genital organs, skin, hair, blood vessels, bone, and pelvic muscles.

The major estrogen secreted by the ovary is 17β-estradiol; this is converted to estrone in the blood. Estriol is the principal estrogen formed by the placenta during pregnancy. These three compounds, 17β-estradiol, estrone, and estriol, account for most of the estrogenic activity in humans.

The ability of estrogens to suppress secretion of follicle-stimulating hormone (FSH) by the pituitary gland and thereby inhibit ovulation makes estrogen and estrogenlike compounds major components in oral contraceptives. Estrogen replacement therapy (ERT) uses synthetic estrogen (e.g., Premarin), typically given with progestins (e.g., Provera) to treat the physical changes of menopause , including hot flashes and vaginal dryness. ERT also retards the development of osteoporosis in postmenopausal women but increases the risk of breast cancer , heart attack (see infarction ), stroke , and, when not given with progestins, uterine cancer. Estrogens are also used to treat prostate cancer.

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estrogen

The Oxford Pocket Dictionary of Current English | 2009 | © The Oxford Pocket Dictionary of Current English 2009, originally published by Oxford University Press 2009. (Hide copyright information) Copyright

es·tro·gen / ˈestrəjən/ • n. any of a group of steroid hormones that promote the development and maintenance of female characteristics of the body. Such hormones are also produced artificially for use in oral contraceptives or to treat menopausal and menstrual disorders. DERIVATIVES: es·tro·gen·ic / ˌestrəˈjenik/ adj.

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Free newspaper and magazine articles

Free Article Estrogen metabolism and the diet-cancer connection: rationale for assessing the ratio of urinary hydroxylated estrogen metabolites. (Estrogen Metabolism/Cancer Review).
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Magazine article from: FDA Consumer; 4/1/1995
Free Article Estrogen and Alzheimer's Disease.(Pamphlet)
Newspaper article from: Pamphlet by: National Institute on Aging; 5/1/1998

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