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colchicine

colchicine , alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffron ). The metabolic effect of colchicine is not known, but it is thought that it may decrease production of lactic acid and prevent accumulation of uric acid crystals in the body, making it useful in the treatment of gout. Colchicine and derivatives such as demecolcine inhibit mitosis , or cell division. As a mitotic poison, it inhibits rapidly proliferating cells and has been used in cancer therapy and as an immunosuppressive drug . Colchicine has also been used to visualize chromosomes photomicrographically and to induce mutations experimentally.

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colchicine

A Dictionary of Food and Nutrition | 2005 | | Â© A Dictionary of Food and Nutrition 2005, originally published by Oxford University Press 2005. (Hide copyright information) Copyright

colchicine An alkaloid isolated from the meadow saffron, or autumn crocus (Colchicum spp.). It is an old remedy for gout. It inhibits cell division, and is used in experimental horticulture to produce plants with abnormal numbers of chromosomes.

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DAVID A. BENDER. "colchicine." A Dictionary of Food and Nutrition. 2005. Encyclopedia.com. 5 Jul. 2009 <http://www.encyclopedia.com>.

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colchicine

A Dictionary of Biology | 2004 | Â© A Dictionary of Biology 2004, originally published by Oxford University Press 2004. (Hide copyright information) Copyright

colchicine An alkaloid derived from the autumn crocus, Colchicum autumnale. It inhibits spindle formation in cells during mitosis so that chromosomes cannot separate during anaphase, thus inducing multiple sets of chromosomes (see polyploid). Colchicine is used in genetics, cytology, and plant breeding research and also in cancer therapy to inhibit cell division.

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Free newspaper and magazine articles

	FDA to crack down on companies marketing injectable colchicines.(Recalls/warnings)(food and drug administration) Magazine article from: Adverse Event Reporting News; 2/12/2008
	Ginkgo and Colchicine: Curiouser and Curiouser, says Alice. (Phytotherapy Review).(colchicine in placental blood) Magazine article from: Townsend Letter for Doctors and Patients; 4/1/2002
	Deaths from intravenous colchicine resulting from a compounding pharmacy error--Oregon and Washington, 2007.(Case study) Newspaper article from: Morbidity and Mortality Weekly Report; 10/12/2007

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	FDA to crack down on companies marketing injectable colchicines.(Recalls/warnings)(food and drug administration) Magazine article from: Adverse Event Reporting News; 2/12/2008; 528 words ; ...companies marketing unapproved injectable colchicine, a drug used to treat gout. Colchicine is a highly toxic drug that can easily be...events associated with the use of intravenous colchicine, including 23 deaths, the agency stated... Read more
	Ginkgo and Colchicine: Curiouser and Curiouser, says Alice. (Phytotherapy Review).(colchicine in placental blood) Magazine article from: Townsend Letter for Doctors and Patients; 4/1/2002; ; 700+ words ; ...compound present which they identified as colchicine. (1) Naturally the scientists were curious...pregnant women. Only five of these contained colchicine and the group reported that all of the colchicine-containing blood samples came from women... Read more
	Deaths from intravenous colchicine resulting from a compounding pharmacy error--Oregon and Washington, 2007.(Case study) Newspaper article from: Morbidity and Mortality Weekly Report; 10/12/2007; ; 700+ words ; Colchicine for injection has been available in the United States...medicine providers but is not an accepted practice. Colchicine has well-known toxicities that limit its safe therapeutic...persons from Washington and Oregon died after receiving IV colchicine for back pain from an alternative medicine ... Read more
	Colchicine for dermatologic diseases. Magazine article from: Journal of Drugs in Dermatology; 3/1/2005; ; 700+ words ; ...authors review all aspects related to colchicine from its pharmacology to its usage in...skin diseases. ******** Introduction Colchicine has been prescribed in dermatology for...usage in several skin diseases. History Colchicine** is an alkaloid extracted from the seeds... Read more
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	The production of glutathione by inducing MRP expression. (Senior Division).(Brief Article) Magazine article from: Journal of the Colorado-Wyoming Academy of Science; 4/1/2002; ; 213 words ; ...were given an anti-inflammatory drug, colchicine, to induce MRP expression, to potentially...experimental group received 0.5 mg/kg of colchicine; the other experimental group received 1.0 mg/kg of colchicine. The control group received no colchicine... Read more
	Concord Labs nets letter for faulty investigations. Newspaper article from: Validation Times; 8/1/2006; 395 words ; A Feb. 23 through March 22, FDA investigation of the Concord Labs, Fairfield, NJ, the maker of colchicine tablets, hyoscyamine sulfate tablets and nitroglycerin sublingual tablets, documented deviations from current GMP regulations... Read more
	Positive impact of chloroquine on delayed pressure urticaria.(CASE REPORTS)(Clinical report) Magazine article from: Journal of Drugs in Dermatology; 4/1/2007; ; 700+ words ; ...relief of the symptoms. One month later, colchicine 1.2 mg/day was added with some additional...addition to prednisolone 10 mg/day, colchicine 1.2 mg/day, and cetirizine 10 mg/day...September 2005, prednisolone 10 mg/day, colchicine 1.2 mg/day, and cetirizine 10 mg/day... Read more
	Familial Mediterranean fever and acute anterior myocardial infarction in a young patient/Genc bir hastada ailevi Akdeniz atesi ve akut on cidar miyokard infarktusu.(Case Report/Olgu Sunumu)(Clinical report) Magazine article from: The Anatolian Journal of Cardiology (Anadolu Kardiyoloji Dergisi); 9/1/2006; ; 700+ words ; ...laboratory evidence for localized and systemic inflammation (1). Colchicine treatment usually prevents the attacks and the associated...was being followed because of FMF for ten years. He was on colchicine treatment except last two years. During FMF attacks, he had... Read more