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guanine

guanine (gwä´nēn), organic base of the purine family. It was reported (1846) to be in the guano of birds; later (1879–84) it was established as one of the major constituents of nucleic acids. The accepted structure of the guanine molecule was proposed in 1875, and the compound was first synthesized in 1900. When combined with the sugar ribose in a glycosidic linkage, guanine forms a derivative called guanosine (a nucleoside), which in turn can be phosphorylated with from one to three phosphoric acid groups, yielding the three nucleotides GMP (guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate). Analogous nucleosides and nucleotides are formed from guanine and deoxyribose. The nucleotide derivatives of guanine perform important functions in cellular metabolism. GTP acts as a coenzyme in carbohydrate metabolism and in the biosynthesis of proteins; it can readily donate one of its phosphate groups to adenosine diphosphate (ADP) to form adenosine triphosphate (ATP), an extremely important intermediate in the transfer of chemical energy in living systems. GTP is the source of the guanosine found in RNA and deoxyguanosine triphosphate (dGTP) is the source of the deoxyguanosine in DNA, and thus guanine is intimately involved in the preservation and transfer of genetic information. Guanine is said to account for the iridescence of fish scales and the white, shiny appearance of the skin of many amphibians and reptiles.

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"guanine." The Columbia Encyclopedia, 6th ed.. . Encyclopedia.com. 22 Aug. 2017 <http://www.encyclopedia.com>.

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"guanine." The Columbia Encyclopedia, 6th ed.. . Retrieved August 22, 2017 from Encyclopedia.com: http://www.encyclopedia.com/reference/encyclopedias-almanacs-transcripts-and-maps/guanine

guanine

gua·nine / ˈgwänēn/ • n. Biochem. a compound, C5H5N5O, that occurs in guano and fish scales, and is one of the four constituent bases of nucleic acids. A purine derivative, it is paired with cytosine in DNA.

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"guanine." The Oxford Pocket Dictionary of Current English. . Encyclopedia.com. 22 Aug. 2017 <http://www.encyclopedia.com>.

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"guanine." The Oxford Pocket Dictionary of Current English. . Retrieved August 22, 2017 from Encyclopedia.com: http://www.encyclopedia.com/humanities/dictionaries-thesauruses-pictures-and-press-releases/guanine

guanine

guanine (gwah-neen) n. one of the nitrogen-containing bases (see purine) that occurs in the nucleic acids DNA and RNA.

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"guanine." A Dictionary of Nursing. . Encyclopedia.com. 22 Aug. 2017 <http://www.encyclopedia.com>.

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guanine

guanine A purine derivative. It is one of the major component bases of nucleotides and the nucleic acids DNA and RNA.

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"guanine." A Dictionary of Biology. . Encyclopedia.com. 22 Aug. 2017 <http://www.encyclopedia.com>.

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guanine

guanine A purine base found in nucleic acids. See also adenine, cytosine, and thymine.

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"guanine." A Dictionary of Ecology. . Encyclopedia.com. 22 Aug. 2017 <http://www.encyclopedia.com>.

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guanine

guanine A purine base that occurs in both DNA and RNA.

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"guanine." A Dictionary of Plant Sciences. . Encyclopedia.com. 22 Aug. 2017 <http://www.encyclopedia.com>.

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guanine

guanine A purine base that occurs in both DNA and RNA.

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"guanine." A Dictionary of Zoology. . Encyclopedia.com. 22 Aug. 2017 <http://www.encyclopedia.com>.

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guanine

guanine One of the purines.

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"guanine." A Dictionary of Food and Nutrition. . Encyclopedia.com. 22 Aug. 2017 <http://www.encyclopedia.com>.

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"guanine." A Dictionary of Food and Nutrition. . Retrieved August 22, 2017 from Encyclopedia.com: http://www.encyclopedia.com/education/dictionaries-thesauruses-pictures-and-press-releases/guanine