shikimic acid pathway

shikimic acid pathway The key metabolic pathway in the biosynthesis of the aromatic amino acids – tyrosine, phenylalanine, and tryptophan – which occurs in plants, bacteria, and fungi, but not in animals. This series of reactions makes these amino acids available to animals, for which they are essential amino acids, required in the diet for proteins and as precursors for a wide range of aromatic molecules. The initial step of the pathway is the condensation of erythrose-4-phosphate (from the pentose phosphate pathway) and phosphoenolpyruvate (from glycolysis). The product of this is then cyclized and reduced to form the intermediate compound shikimate, with the phenolic ring structure characteristic of the aromatic amino acids. Combination with a further molecule of phosphoenolpyruvate produces chorismate, from which alternative pathways lead to either phenylalanine/tyrosine or to tryptophan. An enzyme responsible for a step in the conversion of shikimate to its immediate derivative, 3-enolpyruvyl-shikimate-5-phosphate, is inhibited by the herbicide glyphosate, thus blocking the biosynthesis of aromatic amino acids by the plant.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"shikimic acid pathway." A Dictionary of Biology. 2004. Encyclopedia.com. 23 Oct. 2014 <http://www.encyclopedia.com>.

"shikimic acid pathway." A Dictionary of Biology. 2004. Encyclopedia.com. (October 23, 2014). http://www.encyclopedia.com/doc/1O6-shikimicacidpathway.html

"shikimic acid pathway." A Dictionary of Biology. 2004. Retrieved October 23, 2014 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O6-shikimicacidpathway.html

Learn more about citation styles

Related newspaper, magazine, and trade journal articles from Questia

(Including press releases, facts, information, and biographies)

Differential Effects of Glyphosate and Roundup on Human Placental Cells and...
Magazine article from: Environmental Health Perspectives ...herbicide Roundup; it inhibits the shikimic acid pathway that is important for plant protein...Cox 1998). Roundup contains acid glyphosate and adjuvants such as...Roundup (containing 360 g/L acid glyphosate; Monsanto, Anvers...
The Continuing Promise of Natural Products for Drug Development
Magazine article from: The American Biology Teacher ...discovery of the biosynthetic pathway by which artemisinin is...synthesis in E. coli of shikimic acid, the starter molecule...and-match approach to pathway construction. Various...protein or protein-nucleic acid interactions responsible...

For more facts and information, see all results

For students and teachers!

Encyclopedia.com provides students and teachers facts, information, and biographies from verified, citable sources, including:

Encyclopedia.com provides students and teachers facts, information, and biographies from verified, citable sources, including: