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cytosine
cytosine
cytosine A
pyrimidine derivative. It is one of the principal component bases of
nucleotides and the nucleic acids
DNA and
RNA.
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Mutant cytosine deaminase is an effective prodrug converter.
Newspaper article from: Gene Therapy Weekly; 9/23/2004; 700+ words
; ...com & NewsRx.net) -- Mutant cytosine deaminase is an effective prodrug converter...Escherichia coli gene, codA, encodes cytosine deaminase and is introduced into cancer...investigators in the United States report. "Cytosine deaminase converts 5-FC into cytotoxic...
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A Molecular Dynamics Study of the Ligand Release Path in Yeast Cytosine Deaminase
Magazine article from: Biophysical Journal; 4/1/2007; ; 700+ words
; ABSTRACT Yeast cytosine deaminase, a zinc metalloenzyme, catalyzes the deamination of cytosine to uracil. Experimental and computational...with one much more favored than the other. Cytosine is pushed out of the active site by a restraint...
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Combined Cytosine Deaminase/Thymidine Kinase Gene Therapy Eradicates Glioma in Animal Model.
Newspaper article from: Cancer Weekly; 11/21/2000; 700+ words
; ...Combination suicide gene therapy using the cytosine deaminase and the thymidine kinase gene...TK) gene and the Escherichia coli cytosine deaminase (CD) gene, via a recombinant...Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene...
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The Triplex-Hairpin Transition in Cytosine-Rich DNA
Magazine article from: Biophysical Journal; 12/1/2004; ; 700+ words
; ...coupling between ionization and folding in cytosine-rich triple-helical triplexes. INTRODUCTION...GC^sup +^ Hoogsteen pair requires cytosine to be protonated at the N3 position...1990). An increase in pH induces cytosine deprotonation and destabilizes the CG...
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Cytosine methylation enhances AFB1-induced guanine mutations at CpG sites.
Newspaper article from: Gastroenterology Week; 11/24/2003; 548 words
; ...NewsRx.com & NewsRx.net) -- Cytosine methylation enhances AFB1-induced guanine...carcinogen targeting and the role of cytosine methylation on the mutation spectrum...sequencing. The results indicated that cytosine methylation enhances AFB1-induced guanine...
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Cytosine arabinoside-induced vasculitis
Magazine article from: Mayo Clinic Proceedings; 3/1/1998; ; 700+ words
; Dermatologic side effects of cytosine arabinoside (ara-C) are rare and most...nonlymphoblastic leukemia; ara-C = cytosine arabinoside; HUEC = human umbilical vein endothelial cells Cytosine arabinoside (ara-C) is a chemotherapeutic...
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FIS-HAM Salvage Therapy Effective Despite Toxicity.(fludarabine, cytosine arabinoside, and mitoxantrone is an effective treatment for advanced leukemia)
Newspaper article from: Cancer Weekly; 8/21/2001; 700+ words
; ...salvage regimen consisting of fludarabine, cytosine arabinoside, and mitoxantrone (FIS...fludarabine with 750 mg/m(2) infusions of cytosine arabinoside every three hours on the...intermittent sequential high-dose cytosine arabinoside, and mitoxantrone [FIS...
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German Inventors Develop Cytosine Methylation Detection Method
News Wire article from: US Fed News Service, Including US State News; 9/19/2008; 499 words
; ...developed a bovine for method for detecting cytosine methylation patterns . According to the...method is described for the analysis of cytosine methylation patterns in genomic deoxyribonucleic...with a bisulfite, in such a way that cytosine is converted into a base that is different...
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Mutant p53 and aberrant cytosine methylation silence gene expression.
Newspaper article from: Cancer Weekly; 8/12/2003; 690 words
; ...NewsRx.net) -- Mutant p53 and aberrant cytosine methylation silence gene expression...silenced in association with aberrant cytosine methylation of their promoters. Despite...in Oncogene (Mutant p53 and aberrant cytosine methylation cooperate to silence gene...
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High-Dose Cytosine Arabinoside-Based Regimens Effective As Salvage Therapy.(Brief Article)
Newspaper article from: AIDS Weekly; 2/11/2002; 700+ words
; ...Researchers in California say that high-dose cytosine arabinoside (Ara-C)-based chemotherapy...remission in 13 patients (High-dose cytosine-arabinoside and cisplatin regimens...in this study include: * High-dose cytosine arabinoside (Ara-C)-based chemotherapy...
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cytosine
Book article from: A Dictionary of Plant Sciences
cytosine A pyrimidine base that occurs in both DNA and RNA .
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Mutagen
Book article from: Genetics
...four DNA bases (adenine, thymine, cytosine, and guanine). Because of this similarity...replication, while the other mimics cytosine and therefore pairs with guanine. In...adenine. If it then converts to its cytosine-like form, during the next round of...
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DNA Repair
Book article from: Genetics
...natural DNA bases: adenine, guanine, cytosine, or thymine (A, G, C, or T). The...whereas loss of the "pyrimidine" bases (cytosine and thymine) is called depyrimidination...amino group (-NH 2 ). For example, cytosine (C), which is paired with guanine...
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DNA
Book article from: American Decades
...adenine, thymidine, guanine, and cytosine) attached to a sugar-phosphate backbone...bonds to a thymidine, and a guanine to a cytosine; this assures that the two strands always...side of the molecule will only bind to a cytosine. The cytosine on the other side will...
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Evolution, Molecular
Book article from: Genetics
...the four "bases" (uracil, adenine, cytosine, and guanine) is appended. While phosphate...Stanley Miller in his preparation of cytosine. More challenging to those studying...have reacted with the bases (especially cytosine and uracil) and acquired the phosphate...
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