pyridine
pyridine or azine , C 5 H 5 N, colorless, flammable, toxic liquid with a putrid odor. It melts at -42°C and boils at 115.5°C. Chemically, it is a heterocyclic aromatic tertiary amine (see under amino group ). Its molecule resembles that of benzene, one carbon-hydrogen unit in the benzene ring being replaced with a nitrogen molecule. It is miscible with water and with most organic solvents. Its aqueous solution is slightly alkaline. Pyridine is used as a solvent, as a denaturant for alcohol, and as a starting material in the synthesis of other compounds. Compounds that can be derived from pyridine include antihistamines and vitamins. Pyridine is obtained from bone oil or from coal tar by destructive distillation, which decomposes alkaloids that contain it. Alkaloids that contain pyridine include coniine, piperine (the alkaloid in pepper), and nicotine (present in tobacco); free pyridine is present in tobacco smoke.
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New acromegaly study results reported from University of Munich.
Newspaper article from: Health & Medicine Week; 9/22/2008; 700+ words
; The estimated prevalence of acromegaly is 40-125 per million. The diagnosis of acromegaly is often delayed due to deficits in recognizing...investigators in Munich, Germany report (see also Acromegaly). It is not known how many subjects with...
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European Commission Approves SOMAVERT(R) for the Treatment of Acromegaly.
PR Newswire; 11/19/2002; 700+ words
; ...for the treatment of patients with acromegaly who have had an inadequate response...concentrations or was not tolerated. Acromegaly is a serious, life-shortening disease...dose adjusted studies in patients with acromegaly. In the long-term studies, SOMAVERT...
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Acromegaly.(Review)(Disease/Disorder overview)
Magazine article from: Orphanet Journal of Rare Diseases; 6/25/2008; ; 700+ words
; ...Salenave [1] Disease name and synonyms Acromegaly (derived from the Greek words akros...Italian anatomist, in 1864. Definition Acromegaly is characterized by an acquired progressive...more than 90% of cases. Epidemiology Acromegaly is a rare disease, with a prevalence...
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New study offers hope for patients with acromegaly, a rare, life-threatening hormonal disorder ...; Treatment with Sandostatin LAR may reverse effects of acromegalic cardiomyopathy in young patients.
M2 Presswire; 2/19/2003; 700+ words
; ...study offers hope for patients with acromegaly, a rare, life-threatening hormonal...of death for patients suffering from acromegaly, a rare hormonal disorder which leads...mortality in young patients diagnosed with acromegaly. Globally, an estimated 244,000...
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Investigators at Columbia University zero in on acromegaly.(Report)
Newspaper article from: Biotech Week; 9/23/2009; 700+ words
; ...either from endogenous overproduction in acromegaly or exogenous sources, on skeletal muscle...magnetic resonance imaging (MRI) in acromegaly and test the hypothesis that dual...amp; Metabolism report (see also Acromegaly). "The design was a cross-sectional...
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Growth Hormone (GH) Receptor Isoform in Acromegaly: Lower Concentrations of GH but Not Insulin-Like Growth Factor-1 in Patients with a Genomic Deletion of Exon 3 in the GH Receptor Gene
Magazine article from: Clinical Chemistry; 8/1/2007; ; 700+ words
; ...by the GHR genotype in patients with acromegaly. Methods: Study participants were...patients with established diagnosis of acromegaly. The genotype of the GHR was determined...findings at the time of diagnosis of acromegaly were obtained from the medical records...
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U.S. Food and Drug Administration Approves SOMAVERT(R) for the Treatment Of Acromegaly; First in a New Class of Medicines Treats Debilitating Hormone Disease.
PR Newswire; 3/26/2003; 700+ words
; ...for injection) for the treatment of acromegaly in patients who have had an inadequate...to normalize serum IGF-I levels. Acromegaly is a serious, life-shortening disease...with the disorder(1). Patients with acromegaly often suffer from headache, excessive...
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Findings from University of Brescia broaden understanding of acromegaly risk factors.
Magazine article from: Women's Health Weekly; 1/1/2009; 700+ words
; ...of vertebral fractures in men with acromegaly' have been presented. "Data on osteoporotic fractures in acromegaly are limited. An increased prevalence...in postmenopausal women with active acromegaly," scientists writing in the Journal...
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Studies from University of Duisburg-Essen, Division of Endocrinology have provided new data on acromegaly risk factors.(Report)
Newspaper article from: Biotech Week; 9/9/2009; 700+ words
; ...and sex as predictors of biochemical activity in acromegaly: analysis of 1485 patients from the German Acromegaly Register,' is the subject of a report. "We evaluated the German Acromegaly Register for clinical variables associated with...
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New acromegaly therapy study findings have been reported from National Health Service Trust, Department of Endocrinology.
Newspaper article from: Biotech Week; 9/3/2008; 700+ words
; ...somatostatin analog formulations for therapy of acromegaly,' have been published. "Short and...analogs are approved for clinical use in acromegaly. Recent analysis of the relative efficacy...lanreotide SR on the GH-IGF-I axis in acromegaly favored octreotide LAR in the secondary...
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Acromegaly and Gigantism
Encyclopedia entry from: Gale Encyclopedia of Children's Health: Infancy through Adolescence
Acromegaly and gigantism Definition Acromegaly is a disease in which an abnormality in the pituitary gland...in excessive height and is called gigantism. Description Acromegaly is a disorder in which the abnormal release of a particular...
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acromegaly
Book article from: The Columbia Encyclopedia, Sixth Edition
acromegaly , adult endocrine disorder resulting from hypersecretion of growth hormone...Frequently glucose metabolism is disturbed, leading to diabetes mellitus. Acromegaly is usually caused by a tumor of the pituitary; treatment consists of...
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growth hormone
Book article from: The Oxford Companion to the Body
...oversecretion afterwards results in acromegaly , a condition characterized by coarsening...Interest in dwarfism, gigantism, and acromegaly has spanned the centuries; literature...illustrates some of the chacterisitics of acromegaly, but it was not until the late eighteenth...
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Growth Hormone Tests
Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed.
...hyperpituitarism that is evident in gigantism or acromegaly to screen for inadequate or reduced...these hormones can lead to gigantism or acromegaly, both of which are characterized by...height up to 8 feet (2.5m) or more. Acromegaly results when hGH is overproduced after...
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giants
Book article from: The Oxford Companion to the Body
...problem since the condition of ‘acromegaly’ was first described, and...maturity, constitutes the condition of acromegaly. The symptoms of this illness are legion...terms of the symptoms associated with acromegaly. From a mere historical point of view...
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