Research topic:methotrexate

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methotrexate

The Columbia Encyclopedia, Sixth Edition

methotrexate drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemia , psoriasis , and non-Hodgkin's lymphoma . By binding to an enzyme that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acids and therefore with tissue cell reproduction. Because of its immunosuppressive qualities, it is also used in the treatment of rheumatoid arthritis .


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The Columbia Encyclopedia, Sixth Edition. Copyright 2008 Columbia University Press

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Methotrexate
Methotrexate Definition Methotrexate is a folic acid derivative that interferes with folic acid metabolism...antineoplastic, and immunosuppressant. In the United States, methotrexate is also recognized by the trade names Folex and Mexate, or the... Read more
methotrexate
methotrexate (meth-oh- treks -ayt) n. a drug that interferes with cell growth and is administered by mouth or injection to treat many types... Read more
Leucovorin
...cancer patients who are taking either methotrexate or fluorouracil chemotherapy. Methotrexate is used to treat a wide range of cancers...colorectal cancer. When leucovorin and methotrexate are used together, this therapy is often... Read more
Edatrexate
...experimental) medicine similar to methotrexate used to stop growth of cancer and formation...antagonist of folic acid closely related to methotrexate in its structure and antitumor activity...has several potential advantages over methotrexate, including better transport across... Read more
Folic Acid
...used to counter the side effects of methotrexate and fluorouracil . Description Prior...or folic acid antagonists, such as methotrexate and 5-fluorouracil (5-FU), inhibit...acid) opposes the toxic effects of methotrexate on normal tissue. Leucovorin also increases... Read more

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Methotrexate for Rheumatoid Arthritis

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