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antimetabolite

The Columbia Encyclopedia, Sixth Edition | 2008 | The Columbia Encyclopedia, Sixth Edition. Copyright 2008 Columbia University Press. (Hide copyright information) Copyright

antimetabolite see metabolite .

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FDA GRANTS APPROVAL FOR GENERIC EQUIVALENT TO IMURAN.(Mylan Laboratories' immunosuppressive antimetabolite)
Newspaper article from: Biotech Business; 2/1/2000; 209 words ; ...approval for Azathioprine tablets in 50mg. strength. Azathioprine is the generic equivalent to Imuran, an immunosuppressive antimetabolite manufactured by Glaxo Wellcome Inc. The product is indicated as an adjunct for the prevention of rejection in renal homotransplantation... Read more
Topical 5% 5-fluorouracil cream in the treatment of plantar warts: a prospective, randomized, and controlled clinical study.
Magazine article from: Journal of Drugs in Dermatology; 5/1/2006; ; 700+ words ; Abstract Topical 5-fluorouracil (5-FU) is an antineoplastic antimetabolite that inhibits DNA and RNA synthesis, thereby preventing cell replication and proliferation. This mechanism of action may allow... Read more
A randomized Phase II trial of pemetrexed plus irinotecan (ALIRI) versus leucovorin-modulated 5-FU plus irinotecan (FOLFIRI) in first-line treatment of locally advanced or metastatic colorectal cancer.(Report)
Magazine article from: Advances in Gastrointestinal Cancer; 9/1/2008; ; 700+ words ; ...the addition of irinotecan, oxaliplatin, bevacizumab and cetuximab to available treatments. Pemetrexed is an antifolate/antimetabolite with several molecular targets involved in both pyrimidine and purine neosynthesis: thymidylate synthase (TS), dihydrofolate... Read more
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Magazine article from: Clinical Journal of Oncology Nursing; 10/1/2008; ; 700+ words ; ...developed in 1963 in the former German Democratic Republic with the intention of producing an agent with alkylating and antimetabolite properties. German investigators first used bendamustine to treat MM in 1969 (Anger, Hesse, & Baufeld, 1969). From 1971... Read more
Natural remedies for Herpes simplex.(Herpes simplex)
Magazine article from: Alternative Medicine Review; 6/1/2006; ; 700+ words ; ...arginine is required for HSV replication. (6) Lysine appears to antagonize arginine by several mechanisms: it functions as an antimetabolite of arginine; it competes with arginine for reabsorption at the renal tubule, thereby increasing arginine excretion; it competes... Read more
Hyperthermic intraoperative intraperitoneal chemotherapy safety considerations.
Magazine article from: AORN Journal; 4/1/1996; ; 700+ words ; ...kind or amount of poisonous effect on cells caused by a chemical substance not of biologic origin. * 5-Fluorouracil: An antimetabolite that is used widely to treat breast and gostrointestinal malignancies. * Hyperthermic crisis: A potentially fatal situation... Read more
GENERICS INCURSION CAUSE A CYTOTOXIC MARKET DECLINE.
Newspaper article from: Worldwide Biotech; 1/1/2009; 700+ words ; ...7MM, achieving sales of $2.7bn in 2017. Two newer cytotoxic cancer brands compete for market share Eisai/Johnson & Johnson's Dacogen (decitabine) and Celgene/Nippon Shinyaku's Vidaza (azacitidine) are antimetabolite cytotoxic agents approved i Read more

Related entries from encyclopedias, dictionaries, and thesauruses

antimetabolite
Book article from: A Dictionary of Food and Nutrition antimetabolite Compound that inhibits a normal metabolic process, acting as an analogue of a normal metabolite. Some are useful in chemotherapy... Read more
antibiotic
Book article from: A Dictionary of Ecology antibiotic An antimetabolite obtained from or produced by a living bacterium, fungus, or plant, which, in very small amounts, is toxic or lethal to other organisms... Read more
Azathioprine
Encyclopedia entry from: Gale Encyclopedia of Cancer ...Definition Azathioprine is a non-specific immunosuppressant antimetabolite that can be used as a chemotherapeutic agent to inhibit...Azathioprine is a derivative of mercaptopurine, a purine analog antimetabolite, which interferes with the enzymatic pathways for biosynthesis... Read more
fluorouracil
Book article from: A Dictionary of Nursing fluorouracil (floo-er-oh- yoor -ă-sil) n. a drug that prevents cell growth (see antimetabolite ) and is used in the treatment of solid tumours, such as cancers of the digestive system and breast; it is usually administered... Read more
tioguanine
Book article from: A Dictionary of Nursing tioguanine ( thioguamine ) (ty-oh- gwah -neen) n. a drug that prevents the growth of cancer cells (see antimetabolite ) and is administered by mouth in the treatment of leukaemia. Trade name: Lanvis . Read more

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