Harrison Gray Otis
Harrison Gray Otis 1765-1848, American political leader, b. Boston; nephew of James Otis. He practiced law in Boston, and was elected (1795) to the Massachusetts legislature. A staunch Federalist, he served (1797-1801) in Congress and was again a member of the state legislature from 1802 to 1817. In 1814 he was a leader of the Hartford Convention and subsequently defended that meeting. Otis was a U.S. Senator (1817-22) and mayor of Boston (1829-31). He published Letters Developing the Character and Views of the Hartford Convention (1820) and Otis' Letters in Defence of the Hartford Convention (1824).
Bibliography: See biographical study by S. E. Morison (1913, repr. 1969).
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Tamoxifen benefit lasts 10 years, new data show: the relative risk of breast cancer was reduced by a highly significant 29%, compared with placebo.(Across Specialties)
Magazine article from: Clinical Psychiatry News; 2/1/2007; ; 700+ words
; ...up from a landmark clinical trial of tamoxifen for breast cancer prevention indicates...important for the overall evaluation of tamoxifen in prevention. If you get the same benefit...cancer were randomized to 5 years of daily tamoxifen or placebo. Such a placebo-controlled...
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Tamoxifen prevention trial faltering: NCI faces difficulty recruiting, additional bad news on tamoxifen. (National Cancer Institute)
Magazine article from: The Network News; 1/1/1996; ; 700+ words
; ...been bad ones for the proponents of the tamoxifen prevention trial. In October, it was revealed at a closed-door meeting that tamoxifen failed to prevent heart disease in breast...is no longer able to claim that taking tamoxifen will result in fewer heart attacks...
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Tamoxifen 'breakthrough' a Bitter Pill to Swallow
Magazine article from: Herizons; 7/1/1998; ; 700+ words
; Tamoxifen `breakthrough' a Bitter Pill to Swallow...Institute study that hailed the cancer drug tamoxifen as a preventive treatment for women believed...Canadian. Half of the subjects were given tamoxifen; half a placebo. Among the 6,500...
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Tamoxifen benefit persists 10 years, new data show: risk-benefit ratio rises after first 5 years.(Women's Health)
Magazine article from: Internal Medicine News; 1/15/2007; ; 700+ words
; ...up from a landmark clinical trial of tamoxifen for breast cancer prevention indicates...important for the overall evaluation of tamoxifen in prevention. If you get the same benefit...cancer were randomized to 5 years of daily tamoxifen or placebo. Such a placebo-controlled...
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Tamoxifen Cuts the Risk of Breast Cancer in Half.(Clinical report)
Newspaper article from: Family Practice Alert; 12/1/1998; 700+ words
; Tamoxifen Cuts the Risk of Breast Cancer in Half...risk of thromboembolism, the use of tamoxifen reduces a womans risk of developing breast...cancer who took adjuvant therapy with tamoxifen not only had a significantly lower rate...
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Tamoxifen-aromatase inhibitor combo improves Ca outcomes.(News)
Magazine article from: OB GYN News; 2/1/2005; ; 700+ words
; ...inhibitor following 2-3 years of adjuvant tamoxifen results in markedly better disease...than the traditional 5 full years of tamoxifen, according to three major randomized...anastrozole (Arimidex) after 2 years of tamoxifen. He reported on more than 3,100 breast...
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Tamoxifen-Resistant Breast Cancers Alter Their Traits, Become Receptive to New Therapies.
News Wire article from: Ascribe Higher Education News Service; 12/13/2002; 700+ words
; ...tumors that stop responding to the drug tamoxifen actually change their cellular characteristics...the process of becoming resistant to tamoxifen, the tumors alter their qualities and...conducted in a new mouse strain with tamoxifen-resistant tumors - at the 25th annual...
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Tamoxifen breakthrough a bitter pill to swallow [National Cancer Institute]
Magazine article from: Herizons; 7/1/1998; ; 700+ words
; ...Institute study that hailed the cancer drug tamoxifen as a preventive treatment for women believed...Canadian. Half of the subjects were given tamoxifen; half a placebo. Among the 6,500 taking tamoxifen, the breast cancer rate was 1.3...
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Tamoxifen study results are mixed bag.
News Wire article from: United Press International; 9/12/2002; 700+ words
; ...Intervention Study trial of the drug tamoxifen, involving 7,000 women at high risk for breast cancer, Thursday said tamoxifen results in a reduction in breast...four women out of 3,500 who took tamoxifen for an average of 40 months got...
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Tamoxifen-resistant tumors alter their traits, become receptive to new therapies.
Newspaper article from: Cancer Weekly; 1/21/2003; 700+ words
; ...tumors that stop responding to the drug tamoxifen actually change their cellular characteristics...the process of becoming resistant to tamoxifen, the tumors alter their qualities and...conducted in a new mouse strain with tamoxifen-resistant tumors - at the 25th annual...
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Tamoxifen
Encyclopedia entry from: Gale Encyclopedia of Cancer
Tamoxifen Definition Tamoxifen (also known as Nolvadex) is a synthetic compound similar to estrogen...but blocks the effects of estrogen on breast tissue. Purpose Tamoxifen is used as adjuvant hormonal therapy immediately after surgery...
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tamoxifen
Book article from: The Columbia Encyclopedia, Sixth Edition
tamoxifen , synthetic hormone used in the treatment of breast cancer . Introduced in 1978, tamoxifen is used to prevent recurrences of cancer...high risk for breast cancer showed that tamoxifen can also prevent first occurrence of...
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Breast Cancer
Encyclopedia entry from: Encyclopedia of Public Health
...measures (surgery and radiation therapy). Tamoxifen (a selective estrogen-receptor modulator...is unknown benefit from treatment with tamoxifen for five years. Both of these interventions...risk of mortality from breast cancer. Tamoxifen also decreases the risk of a second primary...
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Endometrial Cancer
Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed.
...risk for developing endometrial cancer. Tamoxifen. This drug, which is used to treat...chance of developing endometrial cancer. Tamoxifen users tend to have more advanced endometrial...In many cases, however, the value of tamoxifen for treating breast cancer and for preventing...
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Raloxifene
Encyclopedia entry from: Gale Encyclopedia of Cancer
...apoptosis, and growth factor secretion. In 2000 the STAR (Study of Tamoxifen and Raloxifene) study began. The purpose of this double-blind study is to evaluate the use of tamoxifen (another type of SERM) and raloxifene over a five year period...
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