Gatún Lake
Gatún Lake , artificial lake, 163 sq mi (422 sq km), Colón Prov., Panama, formed by the impounding of the Chagres River. Gatún Dam (completed 1912), 1 1/2 mi (2.4 km) long and 115 ft (35 m) high, controls the level of the lake (c.85 ft/26 m above sea level), which is part of the canal route. Barro Colorado Island, high ground to which animals fled as the basin slowly filled, is a wildlife sanctuary. The lower Chagres valley, now submerged, was first selected as a transisthmian route (for a railroad) in 1848 by John Lloyd Stephens, the American author and traveler.
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Methotrexate treatment of psoriasis slowly being incorporated
Magazine article from: Dermatology Times; 6/1/1999; ; 700+ words
; ...teaching points for dermatologists who use methotrexate in the treatment of psoriasis, Howard...the minority among clinicians using methotrexate, but hopefully what we learn from...purpura after a single low dose of methotrexate reinforces the recommendation in the...
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Methotrexate use advocated for Crohn's patients.(Clinical Rounds)
Magazine article from: Pediatric News; 2/1/2008; ; 700+ words
; ...intolerant of thiopurine therapy, methotrexate treatment was both safe and effective...and 12 months after the initiation of methotrexate, he said. At 6 months, 62% were...of the patients when they started methotrexate. Methotrexate "has proven efficacy...
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Methotrexate effective with diffuse lamellar keratitis
Magazine article from: Ophthalmology Times; 10/1/1999; ; 700+ words
; refractive RENO, NV-Methotrexate is an effective treatment to improve...MD. Dr. Buzard reported using methotrexate to manage DLK (the "SOS syndrome...All patients were treated with methotrexate 10 mg once weekly, and seven...
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Methotrexate plus etanercept effective in inducing clinical remission in patients with early moderate-to-severe RA
Magazine article from: Formulary; 8/1/2008; ; 700+ words
; ...with the combination of etanercept and methotrexate was more effective in inducing both...and radiographic nonprogression than methotrexate alone in patients with early moderate...Lancet. The 24-month Combination of Methotrexate and Etanercept in Active Early Rheumatoid...
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Methotrexate overdose: Pancytopenia, oral thrush, pulmonary infection, death: 6 case reports
Magazine article from: Reactions Weekly; 11/15/2008; ; 700+ words
; s Methotrexate overdose Pancytopenia, oral thrush...after inadvertently receiving methotrexate daily instead of monthly. These cases...not stated], was receiving oral methotrexate 5mg once per week with prednisone...
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Gemfibrozil/methotrexate/piperacillin/tazobactam interaction: Acute renal failure (first report of an interaction between methotrexate and gemfibrozil): 2 case reports
Magazine article from: Reactions Weekly; 12/6/2008; ; 700+ words
; Two patients receiving high-dose methotrexate, one receiving concomitant piperacillin...cerebral lymphoma, was treated with methotrexate 2.5 g/m^sup 2^ over 3 hours...first course was well tolerated and methotrexate was eliminated without delay. However...
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First-line methotrexate upheld by Euro panel.(ACROSS SPECIALTIES)
Magazine article from: Skin & Allergy News; 9/1/2009; ; 700+ words
; COPENHAGEN -- Methotrexate is the "anchor drug" for treating...recommendations for managing the disease. "Methotrexate should be part of the first treatment...European Congress of Rheumatology. Methotrexate can be either monotherapy or used...
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First-line methotrexate upheld by Euro panel.(RHEUMATOLOGY)(Report)
Magazine article from: Internal Medicine News; 8/1/2009; ; 700+ words
; COPENHAGEN -- Methotrexate is the "anchor drug" for treating...recommendations for managing the disease. "Methotrexate should be part of the first treatment...European Congress of Rheumatology. Methotrexate can be either monotherapy or used...
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Folic acid used with methotrexate psoriasis treatment for variety of reasons
Magazine article from: Dermatology Times; 6/1/2000; ; 700+ words
; ...supplementation in patients receiving methotrexate for psoriasis, but regimens and rationale...in special circumstances dictated by methotrexate toxicity, and by dose and treatment...for psoriasis patients treated with methotrexate. In the absence of such information...
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Methotrexate remains mainstay
Magazine article from: Dermatology Times; 5/1/2001; ; 700+ words
; PSORIASIS Washington -As methotrexate reaches the 50th anniversary of...reasonably affordable. Although methotrexate is one of the oldest drugs we...University of California, Irvine. Methotrexate is highly effective, with more...
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Methotrexate
Encyclopedia entry from: Gale Encyclopedia of Cancer
Methotrexate Definition Methotrexate is a folic acid derivative that interferes with folic acid...antineoplastic, and immunosuppressant. In the United States, methotrexate is also recognized by the trade names Folex and Mexate, or...
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methotrexate
Book article from: The Columbia Encyclopedia, Sixth Edition
methotrexate drug used in halting the growth of actively proliferating tissues...By binding to an enzyme that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acids and therefore with tissue...
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Leucovorin
Encyclopedia entry from: Gale Encyclopedia of Cancer
...cancer patients who are taking either methotrexate or fluorouracil chemotherapy. Methotrexate is used to treat a wide range of cancers...colorectal cancer. When leucovorin and methotrexate are used together, this therapy is often...
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Leukoencephalopathy
Encyclopedia entry from: Gale Encyclopedia of Cancer
...patients is primarily associated with methotrexate chemotherapy , which is used in treatment...appear years after the administration of methotrexate. Although rare, the incidence of...been shown to occur primarily when methotrexate or cytarabine therapy is used in conjunction...
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Edatrexate
Encyclopedia entry from: Gale Encyclopedia of Cancer
...experimental) medicine similar to methotrexate used to stop growth of cancer and formation...antagonist of folic acid closely related to methotrexate in its structure and antitumor activity...has several potential advantages over methotrexate, including better transport across...
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