Saint Francis, river, c.470 mi (760 km) long, rising in the hills of SE Missouri and flowing S through NE Arkansas to join the Mississippi River near Helena, Ark. The river forms part of the Arkansas–Missouri border. Wappapello Dam (completed 1941), near Poplar Bluff, Mo., forms a reservoir. The river area is popular for recreational activities.

Saint Francis, city (1990 pop. 9,245), Milwaukee co., SE Wis., a residential suburb of Milwaukee on Lake Michigan; inc. 1951. There is meat processing and the manufacture of plastic and metal products. A power plant is there.

Saint Francis, river, Canada: see Saint François.