tamoxifen

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tamoxifen

tamoxifen , synthetic hormone used in the treatment of breast cancer . Introduced in 1978, tamoxifen is used to prevent recurrences of cancer in women who have already undergone surgery to remove their tumors. In 1998, a large study of healthy women at high risk for breast cancer showed that tamoxifen can also prevent first occurrence of the disease: women who took the drug had a 45% lower incidence of cancer that those who received a placebo. However, adverse effects (including uterine cancer) and other concerns await further study.

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tamoxifen

A Dictionary of Nursing | 2008 | Â© A Dictionary of Nursing 2008, originally published by Oxford University Press 2008. (Hide copyright information) Copyright

tamoxifen (tam-oks-i-fen) n. a drug administered orally in the treatment of breast cancer: it binds with hormone receptors in the tumour to inhibit the effect of oestrogens (see anti-oestrogen, selective (o)estrogen receptor modulator). It is also used to induce ovulation in the treatment of female infertility. Trade name: Nolvadex D.

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"tamoxifen." A Dictionary of Nursing. Oxford University Press. 2008. Encyclopedia.com. 29 Nov. 2009 <http://www.encyclopedia.com>.

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"tamoxifen." A Dictionary of Nursing. Oxford University Press. 2008. Retrieved November 29, 2009 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O62-tamoxifen.html

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Free newspaper and magazine articles

	Sequential therapy with tamoxifen and aromatase inhibitors in early-stage postmenopausal breast cancer: a review of the evidence. Magazine article from: Oncology Nursing Forum; 7/1/2008
	Ligand Presents at AACR: Targretin Causes Regression of Tamoxifen-Resistant Breast Tumors in Pre-Clinical Study; Human Clinical Trials Launched in November 1998. Business Wire; 4/13/1999
	Tamoxifen shown to reduce risk of ER-positive breast cancer.(JUST IN)(estrogen receptor) Magazine article from: ONS Connect; 6/1/2007

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Related articles from newspapers, magazines, and more

	Tamoxifen prevention trial faltering: NCI faces difficulty recruiting, additional bad news on tamoxifen. (National Cancer Institute) Magazine article from: The Network News; 1/1/1996; ; 700+ words ; ...been bad ones for the proponents of the tamoxifen prevention trial. In October, it was revealed at a closed-door meeting that tamoxifen failed to prevent heart disease in breast...is no longer able to claim that taking tamoxifen will result in fewer heart attacks...
	Tamoxifen alone discouraged as adjuvant Tx.(Gynecology) Magazine article from: OB GYN News; 5/1/2005; ; 700+ words ; ...aromatase inhibitor, either alone or after tamoxifen therapy, is better than tamoxifen alone for the long-term prevention of breast...survival in postmenopausal women, compared with tamoxifen as a single agent. Consequently, "tamoxifen...
	Tamoxifen benefit lasts 10 years, new data show: the relative risk of breast cancer was reduced by a highly significant 29%, compared with placebo.(Across Specialties) Magazine article from: Clinical Psychiatry News; 2/1/2007; ; 700+ words ; ...up from a landmark clinical trial of tamoxifen for breast cancer prevention indicates...important for the overall evaluation of tamoxifen in prevention. If you get the same benefit...cancer were randomized to 5 years of daily tamoxifen or placebo. Such a placebo-controlled...
	Tamoxifen breakthrough a bitter pill to swallow [National Cancer Institute] Magazine article from: Herizons; 7/1/1998; ; 700+ words ; ...Institute study that hailed the cancer drug tamoxifen as a preventive treatment for women believed...Canadian. Half of the subjects were given tamoxifen; half a placebo. Among the 6,500 taking tamoxifen, the breast cancer rate was 1.3...
	Tamoxifen Prophylaxis Okay in High-Risk Cases.(Brief Article) Magazine article from: Family Practice News; 6/15/1999; ; 700+ words ; ...on breast ca prevention. ATLANTA -- Tamoxifen prophylaxis "may be offered" to women...medical data on the prophylactic use of tamoxifen and raloxifene for lowering breast cancer...recommending that physicians routinely consider tamoxifen prophylaxis for all such women. Also...
	Tamoxifen Cuts the Risk of Breast Cancer in Half.(Clinical report) Newspaper article from: Family Practice Alert; 12/1/1998; 700+ words ; Tamoxifen Cuts the Risk of Breast Cancer in Half...risk of thromboembolism, the use of tamoxifen reduces a womans risk of developing breast...cancer who took adjuvant therapy with tamoxifen not only had a significantly lower rate...
	Tamoxifen 'breakthrough' a Bitter Pill to Swallow Magazine article from: Herizons; 7/1/1998; ; 700+ words ; Tamoxifen `breakthrough' a Bitter Pill to Swallow...Institute study that hailed the cancer drug tamoxifen as a preventive treatment for women believed...Canadian. Half of the subjects were given tamoxifen; half a placebo. Among the 6,500...
	Tamoxifen and Breast Cancer Incidence Among Women with Inherited Mutations in BRCA1 and BRCA2. Newspaper article from: Clinical Oncology Alert; 1/1/2002; 700+ words ; Tamoxifen and Breast Cancer Incidence Among Women...scale. In order to identify whether the tamoxifen benefit realized by high-risk women...mutations. This subgroup was analyzed for tamoxifen vs. placebo use and presence of tumor...
	Tamoxifen has stroke risk, review says; But threat is small, study of trials says Newspaper article from: The Milwaukee Journal Sentinel; 10/12/2004; ; 700+ words ; Tamoxifen has stroke risk, review says But threat...of trials says The breast cancer drug tamoxifen appears to increase a woman's risk...stop breast cancer patients from taking tamoxifen. But it could be a factor for women...
	Tamoxifen benefit persists 10 years, new data show: risk-benefit ratio rises after first 5 years.(Women's Health) Magazine article from: Internal Medicine News; 1/15/2007; ; 700+ words ; ...up from a landmark clinical trial of tamoxifen for breast cancer prevention indicates...important for the overall evaluation of tamoxifen in prevention. If you get the same benefit...cancer were randomized to 5 years of daily tamoxifen or placebo. Such a placebo-controlled...