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suppressor mutation
suppressor mutation (suppressor) In genetics, a second mutation that masks the phenotypic effects of an earlier mutation. This second mutation occurs at a different site in the genome (i.e. it is not a strict reversion). Intragenic suppression results from a second mutation that corrects the functioning of the mutant gene (e.g. a mutation of a different nucleotide in the same triplet, such that the codon then encodes the original amino acid). Intergenic suppression results from mutation of a different gene, the product of which compensates for the dysfunction in the first (e.g. a mutation that produces a mutant transfer-RNA molecule that inserts an amino acid in response to a nonsense codon, thus continuing a protein that would otherwise have been terminated). If a single suppressor mutation can suppress more than one existing mutation, it is said to be a supersuppressor. Compare REVERSE MUTATION.
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MICHAEL ALLABY. "suppressor mutation." A Dictionary of Plant Sciences. 1998. Encyclopedia.com. 1 Jun. 2012 <http://www.encyclopedia.com>. MICHAEL ALLABY. "suppressor mutation." A Dictionary of Plant Sciences. 1998. Encyclopedia.com. (June 1, 2012). http://www.encyclopedia.com/doc/1O7-suppressormutation.html MICHAEL ALLABY. "suppressor mutation." A Dictionary of Plant Sciences. 1998. Retrieved June 01, 2012 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O7-suppressormutation.html |
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suppressor mutation
suppressor mutation In genetics, a second mutation that masks the phenotypic effects of an earlier mutation. This second mutation occurs at a different site in the genome (i.e. it is not a strict reverse mutation); ‘intragenic suppression’ results from a second mutation that corrects the functioning of the mutant gene (e.g. a mutation of a different nucleotide in the same triplet, such that the codon then encodes the original amino acid); ‘intergenic suppression’ results from mutation of a different gene, the product of which compensates for the dysfunction in the first (e.g. a mutation that produces a mutant transfer-RNA molecule that inserts an amino acid in response to a nonsense codon, thus continuing a protein that would otherwise have been terminated). If a single suppressor mutation can suppress more than one existing mutation, it is said to be a supersuppressor.
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Cite this article
MICHAEL ALLABY. "suppressor mutation." A Dictionary of Zoology. 1999. Encyclopedia.com. 1 Jun. 2012 <http://www.encyclopedia.com>. MICHAEL ALLABY. "suppressor mutation." A Dictionary of Zoology. 1999. Encyclopedia.com. (June 1, 2012). http://www.encyclopedia.com/doc/1O8-suppressormutation.html MICHAEL ALLABY. "suppressor mutation." A Dictionary of Zoology. 1999. Retrieved June 01, 2012 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O8-suppressormutation.html |
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