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Biophysical Investigations of Engineered Polyproteins: Implications for Force Data
Magazine article from: Biophysical Journal; 3/1/2005; ; 700+ words
; ...physical properties of these constructed polyproteins. Are the properties of the individual...the use of endogenous heterogeneous polyproteins such as titin (Kellermayer et al...parts? The mechanical unfolding of polyproteins assumes an uncoupled system, where...
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Design of a trans protease lentiviral packaging system that produces high titer virus.(Research)
Magazine article from: Retrovirology; 12/28/2007; ; 700+ words
; ...reading frames to encode two essential polyproteins known as Gag and Gag-Pol. The Gag...concentrations of Gag to Gag-Pol polyproteins are maintained at a ratio of 20:1...the assembly of the Gag and Gag-Pol polyproteins, PR is initially inactive. As the...
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The Mechanical Fingerprint of a Parallel Polyprotein Dimer
Magazine article from: Biophysical Journal; 2/15/2007; ; 700+ words
; ...characteristic sawtooth pattern shape of polyproteins, with peak forces up to 800 pN and...fingerprint of fibers composed of multiple polyproteins that unfolded simultaneously and in...demonstrated that a parallel arrangement of polyproteins could produce such in-register high...
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Understanding strategies for treating HIV.
Magazine article from: MedSurg Nursing; 4/1/1997; ; 700+ words
; ...RNA which generates large, immature viral polyproteins. The immature viral polyproteins are then assembled around a viral RNA core...property of HIV at this stage is that the large polyproteins must be cleaved into smaller, mature proteins...
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Structure-based prediction of potential binding and nonbinding peptides to HIV-1 protease
Magazine article from: Biophysical Journal; 8/1/2003; ; 700+ words
; ...maturation by processing the gag and pol polyproteins of the virus. The cleavage sites in these polyproteins do not have obvious sequence homology...1 protease cleaves the gag and pol polyproteins of the virus to release the structural...
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Relationships of gag-pol diversity between Ty3/Gypsy and Retroviridae LTR retroelements and the three kings hypothesis.(Research article)(Report)
Magazine article from: BMC Evolutionary Biology; 10/8/2008; ; 700+ words
; ...analysis of both gag and pol polyproteins. Our results revealed conflicting...phylogenetic signals between these 2 polyproteins. From that point, we aimed...phylogenetic signals between gag and pol polyproteins in the Ty3/Gypsy and Retroviridae...
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Direct Observation of Markovian Behavior of the Mechanical Unfolding of Individual Proteins
Magazine article from: Biophysical Journal; 7/15/2008; ; 700+ words
; ...treating the mechanical unfolding of polyproteins as the superposition of multiple identical...clamp spectroscopy experiments, polyproteins made of identical tandem repeats of...to analyze the unfolding kinetics of polyproteins with simple Markovian behavior as well...
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Novel bioelectronic method detects HIV-1 drug resistance.
Newspaper article from: Drug Week; 9/24/2004; 700+ words
; ...association of cleaved or uncleaved Gag polyproteins at an electrode surface functionalized...bioelectronic detection of the Gag polyproteins asociated with the surface," wrote...follow the autoprocessing of the Gag polyproteins. The method was applied to determine...
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POTPOURRI: AIDS cure breakthrough
Newspaper article from: Filipino Reporter; 11/21/1996; ; 700+ words
; ...replication or reproduction, it forms large polyproteins (precursors of individual components...particles. However, if the division of polyproteins could be prevented effectively, the...from causing the division of the polyproteins into new viral particles. While research...
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Coronavirus-specific gene-finding system developed.
Newspaper article from: Proteomics Weekly; 12/22/2003; 557 words
; ...the prediction of cleavage sites of viral proteinases in polyproteins into account," researchers in China report. "The cleavage...FEBS Letters (Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS...
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