Peroxisome Proliferator-Activated Receptors and Liver X Receptors in Atherosclerosis and Immunity1,2

From: The Journal of Nutrition | Date: March 1, 2006| Author: Barish, Grant D | Copyright information

ABSTRACT

Atherosclerosis is a primary cause of death in the United States, and the current obesity epidemic threatens to exacerbate its morbidity and mortality worldwide. Despite important cardiovascular treatment advances over the past few decades, new approaches are needed to curb dangerous health trends. Nuclear receptors are a superfamily of ligand-activated transcription factors. The discovery of subfamilies known as peroxisome proliferator-activated receptors (PPAR) and liver X r...

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