CYTOKINES IN THE DIFFERENTIATION THERAPY OF LEUKEMIA: From Laboratory Investigations to Clinical Applications

From: Critical Reviews in Clinical Laboratory Sciences | Date: September 1, 2005| Author: Fung, M C; Mak, N K; Leung, K N | Copyright information

Differentiation therapy of leukemia is the treatment of leukemia cells with biological or chemical agents that induce the terminal differentiation of the cancer cells. It is regarded as a novel and targeted approach to leukemia treatment, based on our better understanding of the hematopoietic process and the mechanisms of its deregulation during leukemogenesis. Clinically, differentiation therapy has been most successful in acute promyelocytic leukemia using all-trans-retinoic acid as the ind...

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