British Journal of Biomedical Science

Factor V Leiden: association with venous thromboembolism in pregnancy and screening issues

British Journal of Biomedical Science | July 1, 2004 | Copyright

ABSTRACT

Disturbances of the natural balance between procoagulant and anticoagulant mechanisms can result in bleeding or thrombotic tendencies. Factor V, on activation by thrombin to factor Va, forms an essential component of the prothrombinase complex, in which it demonstrates its cofactor activity for factor Xa. Down-regulation of factor Va by activated protein C (APC) occurs through cleavage of specific peptide bonds in the heavy chain of the molecule. Factor V Leiden (FV Leiden) is a mutation of factor V that renders factor Va resistant to APC, due to loss of one of these…

Read the rest of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and trade journal articles from HighBeam Research

(Including press releases, facts, information, and biographies)

Factor V Leiden: association with venous thromboembolism in pregnancy and...
Magazine article from: British Journal of Biomedical Science ...Prevalence of FV Leiden varies...for the FV Leiden mutation...populations. The association this inherited...has with venous thromboembolism (VTE) is...established. Pregnancy is notably...interaction with FV Leiden to cause...a routine screening plan for...KEY WORDS: ...

For more facts and information, see all results

Find more facts and information related to the article Factor V Leiden: association with venous ...