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Ca^sup 2+^ Changes the Force Sensitivity of the Hair-Cell Transduction Channel
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ABSTRACT
The mechanically gated transduction channels of vertebrate hair cells tend to close in ~1 ms after their activation by hair bundle deflection. This fast adaptation is correlated with a quick negative movement of the bundle (a "twitch"), which can exert force and may mediate an active mechanical amplification of sound stimuli in hearing organs. We used an optical trap to deflect bullfrog hair bundles and to measure bundle movement while controlling Ca^sup 2+^ entry with a volta...
Related newspaper, magazine, and journal articles from HighBeam Research
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Effects of permeant ion concentrations on the gating of L-type Ca^sup 2+^ channels in hair cells
Biophysical Journal
; ... concentrations further suggested that the dwell time in the closed states might be ion- and concentration-dependent. Contour maps of P^sub o^, time, and test potentials were generated to provide graphic analyses of the charge carrier and concentration-dependence ...
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Ca^sup 2+^ Changes the Force Sensitivity of the Hair-Cell Transduction Channel
Biophysical Journal
; ABSTRACT The mechanically gated transduction channels of vertebrate hair cells tend to close in ~1 ms after their activation by hair bundle deflection. This fast adaptation is correlated with a quick negative movement of the bundle (a "twitch which can exert force and may mediate an active
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Two adaptation processes in auditory hair cells together can provide an active amplifier
Biophysical Journal
; ABSTRACT The hair cells of the vertebrate inner ear convert mechanical stimuli to electrical signals. Two adaptation mechanisms are known to modify the ionic current flowing through the transduction channels of the hair bundles: a rapid process involves Ca^sup 2+^ ions binding to the channels; and
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Pharmacokinetics and Biodistribution of ^sup 111^In- and ^sup 177^Lu-Labeled J591 Antibody Specific for Prostate-Specific Membrane Antigen: Prediction of ^sup 90^Y-J591 Radiation Dosimetry Based on ^sup 111^In or ^sup 177^Lu?
The Journal of Nuclear Medicine
; ^sup 111^In-Labeled antibodies and peptides have been routinely used as chemical and biologic surrogates for ^sup 90^Y-labeled therapeutic agents. However, recent studies have shown that there are significant differences in biodistribution between ^sup 111^In- and ^sup 90^Y-labeled agents. Yttrium
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Synthesis and Biologic Evaluation of ^sup 64^Cu-Labeled Rhenium-Cyclized [alpha]-MSH Peptide Analog Using a Cross-Bridged Cyclam Chelator
The Journal of Nuclear Medicine
; Early detection of cutaneous melanoma is essential, as prognosis with metastatic melanoma is poor. Previous studies showed that ^sup 64^Cu-DOTA-ReCCMSH(Arg^sup 11^) (DOTA is 1,4,7,10-tetraazacyclododecane-N,N',NNtetraacetic acid), a cyclic analog of α-melanocyte-stimulating hormone 945;-MSH),
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Optimization of Radioimmunotherapy of Renal Cell Carcinoma: Labeling of Monoclonal Antibody cG250 with ^sup 131^I, ^sup 90^Y, ^sup 177^Lu, or ^sup 186^Re
The Journal of Nuclear Medicine
; ... subcutaneous SK-RC-52 tumors. Mice received cG250 labeled with ^sup 131^I, ^sup 90^Y-SCN-BzDTPA, ^sup 177^Lu-SCN-Bz-DTPA, or ^sup 186^Re-MAGS intravenously at MTD (protein doses of 30, 30, 60, and 35 g per mouse, respectively). Mice in control groups received unlabeled ...
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Development of a Novel ^sup 99m^Tc-Chelate-Conjugated Bisphosphonate with High Affinity for Bone as a Bone Scintigraphic Agent
The Journal of Nuclear Medicine
; In bone scintigraphy using ^sup 99m^Tc with methylenediphosphonate (^sup 99m^Tc-MDP) and hydroxymethylenediphosphonate (^sup 99m^Tc-HMDP), it takes 2-6 h after an injection before imaging can start. This interval could be shortened with a new radiopharmaceutical with higher affinity for bone. Here,
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CD4^sup +^CD25^sup +^ Regulatory T Lymphocytes in Malignant Pleural Effusion
American Journal of Respiratory and Critical Care Medicine
; Background: Active suppression by CD4^sup +^CD25^sup +^ regulatory T lymphocytes plays an important role in the downregulation of T-cell responses to foreign and self-antigens. Objective: To analyze whether the CD4^sup +^CD25^sup +^ regulatory T lymphocytes exist and function normally in malignant
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Low-Affinity Na^sup +^ Uptake in the Halophyte Suaeda maritima1[C][W][OA]
Plant Physiology
; Na^sup +^ uptake by plant roots has largely been explored using species that accumulate little Na^sup +^ into their shoots. By way of contrast, Nathe halophyte Suaeda maritima accumulates, without injury, concentrations of the order of 400 mM NaCl in its leaves. Here we report that cAMP and Ca^sup
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Good vibrations. (hair cells hold the secret of hearing)(includes related articles on the pinna and insects that can hear bat ultrasound) (Cover Story)
Discover
; WE'RE UNDER SIEGE from age, drugs, and rock and roll, and all that stands between us and utter silence is 32,000 dancing hearing receptors. THE LANK-HAIRED teenager in the black T-shirt was stunned. We were both standing in the damp twilight outside San Francisco's Cow Palace, waiting for the doors
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