UVR, Vitamin D and Three Autoimmune Diseases-Multiple Sclerosis, Type 1 Diabetes, Rheumatoid Arthritis

From: Photochemistry and Photobiology | Date: November 1, 2005| Author: | Copyright information

UV Radiation, Vitamin D and Human Health: An Unfolding Controversy

ABSTRACT

We review the evidence indicating a possible beneficial role for UVR on three Th1-mediated autoimmune diseases: multiple sclerosis, type 1 diabetes and rheumatoid arthritis in relation to recent developments in photoimmunology. Recent work suggests that UVR exposure may be one factor that can attenuate the autoimmune activity leading to these three diseases through several pathways involving UVB and UVA irradiation, UVR-derived vitamin D synthesis and other routes such as α-melanocyte-stimulating hormone, ...

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