Relationship between plasma homocysteine, vitamin status and extracranial carotid-artery stenosis in the Framingham Study ...

From: The Journal of Nutrition | Date: April 1, 1996| Author: | Copyright information

Almost 25 years ago McCully (1969) reported that a child dying of homocystinuria, cystathionuria and methylmalonic aciduria, secondary to abnormality of cobalamin metabolism, exhibited arterial lesions that were strikingly similar to those seen in patients with cystathionine beta synthase deficiency. These observations led to the proposal that the markedly elevated plasma homocysteine concentrations found in persons with homocystinuria were responsible for the development of premature occlusive vascular disease. In recent years this association between plasma homocysteine concentration and ...

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