A Mutation in Sphingolipid Synthesis Suppresses Defects in Yeast Ergosterol Metabolism

From: Lipids | Date: August 1, 2004| Author: | Copyright information

ABSTRACT: A mutation in an otherwise nonessential ERG2 gene is synthetically lethal when combined with mutations in two transcription factors encoded by the UPC2 and ECM22 genes. Employing UV mutagenesis, we isolated a suppressor of the triple mutant erg2Δ upc2Δ ecm22Δ. The morpholine-resistant phenotype of the suppressor was used to identify the suppressor as a mutation in the ELO3 gene. In an expression study on tridemorph-containing medium, using the inducible GAL1 promoter fused to the ELO3 open reading frame, we demonstrated that suppression occurred only when ELO3 was not ...

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