Ischemia-induced arrhythmia: the role of connexins, gap junctions, and attendant changes in impulse propagation* From: Journal of Electrocardiology | Date: October 1, 2005| Author: Johnson, Timothy A; Muller-Borer, Barbara J; Yang, Hua; Cascio, Wayne E | Copyright Churchill Livingstone Inc., Medical Publishers Oct 2005. Provided by ProQuest LLC.Copyright information

Abstract

Sudden cardiac death accounts for more than half of all cardiovascular deaths in the US, and a large proportion of these deaths are attributed to ischemia-induced ventricular fibrillation. As such, the mechanisms underlying the initiation and maintenance of these lethal rhythms are of significant clinical and scientific interest. In large animal hearts, regional ischemia induces two phases of ventricular arrhythmia. The first phase (1A) occurs between 5 and 7 min after arrest ...

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