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Optimizing Injected Dose in Clinical PET by Accurately Modeling the Counting-Rate Response Functions Specific to Individual Patient Scans
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To optimize the injected dose of radiopharmaceutical in PET, one needs to know its relationship to some metric of data quality for individual patient scans, such as noise-equivalent counting rate (NECR). In this paper, we show how one may accurately model the clinical NECR response corresponding to specific patient scans much as if a counting-rate test had been performed on each patient. We apply this technique to patient data and show how it can lead to improved clinical scanning protocols. Methods: True and random coincidence rates expressed as functions of an appropriate measurable system ...
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A Lesion Detection Observer Study Comparing 2-Dimensional Versus Fully 3-Dimensional Whole-Body PET Imaging Protocols
; ...70- kg patient was achieved for an injected dose of approximately 444 MBq (12 mCi...to those corresponding to a 444-MBq injected dose in fully 3D and 2D and a 740-MBq (20 mCi) injected dose in 2D that was considered as the maximum...
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Optimization of injected dose based on noise equivalent count rates for 2- and 3-dimensional while-body PET
; ...to derive guidelines on the optimal injected dose to the patient for 2-dimensional (2D...our approach and estimation of the injected dose that maximizes NEC rate as a function...This correlation allows modifying the injected dose as a function of patient body mass...
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Factors affecting the hepatobiliary excretion of (99m)Tc-MAG3: Its clinical significance in routine renography
; ...was determined as a percentage of the injected dose. Results: The MAG3 quality control...was determined as a percentage of the injected dose, at 35 min after injection. The fasting...mean +/SD, 0.13% +/- 0.15%) of the injected dose at 35 min. The global kidney uptake...
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Optimizing Experimental Protocols for Quantitative Behavioral Imaging with ^sup 18^F-FDG in Rodents
; ...and then normalized for the injected dose or weight of the animal. The...the SUV must be scaled to the injected dose or an arterial plasma sample...compare SUVs scaled to both the injected dose and several arterial plasma...
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Human biodistribution and dosimetry of the PET perfusion agent copper-62-PTSM
; ...units of mCi/cc. Using standard organ weights, the percent injected dose per organ was calculated. Biodistribution data were obtained...of 0.0886 rad/mCi. This organ defined the maximum single injected dose at 56 mCi using the limit of 5 rads to a critical organ per...
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(99m)Tc-N-NOET imaging for myocardial perfusion: Can it offer more than we already have?
; ...myocardial uptake in humans, with 3% of the injected dose in the heart 5 min after injection (2...Tc-N-NOET has a better myocardial uptake (3% of injected dose vs. 1.2% and 1.5% of injected dose for technetium complexes) and a higher...
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Safety, biodistribution, and dosimetry of (99m)Tc-HYNIC-annexin V, a novel human recombinant annexin V for human application
; ...Results: The kidneys accumulated 49.7 + or - 8.1 percentage injected dose (%ID) at 3 h after injection; the liver, 13.1 + or - 1.0...intravenous administration of these tracers, about 75% of the injected dose was eliminated through the urine and 25% through the feces...
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Newer agent steps in as vancomycin fails with infections
; Injected dose of quinupristin/dalfopristin IV results in 97-percent cure or improvement...the antibiotic of last resort." Cure rates In the former group, an injected dose of Synercid (7.5 mg/kg every eight hours for a median 22 days) cured...
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Pretargeting with Bispecific Anti-Renal Cell Carcinoma x Anti-DTPA(In) Antibody in 3 RCC Models
; ...SK-RC-1 [278 130 %ID/g (percentage injected dose per gram), 1 h after injection] >...a relatively small fraction of the injected dose eventually localizes in the tumor...high uptake (80 %ID/g [percentage injected dose per gram]) and good retention of the...
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Myocardial Perfusion Imaging Protocols: Is There an Ideal Protocol?*
; ...however, only about 3%-5% of the total injected dose localizes in the myocardium when injected...relatively short myocardial retention. The injected dose is low (74-148 MBq [3-4 mCi]). The...99m^Tc-sestamibi is ~1.2%-1.5% of the injected dose. Unlike ^sup 201^Tl, ^sup ...
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