To the Editor. Although chloramphenicol is well known to be associated with bone marrow aplasia, I describe the first case, to my knowledge, of paroxysmal nocturnal hemoglobinuria (PNH) in a patient after treatment with chloramphenicol. This case may provide insight into the mechanism of chloramphenicol toxicity.

Report of a Case. A 78-year-old man was referred for hematuria. He had a 5-year history of mild hypertension treated with hydrochlorothiazide at 25 mg/d and had undergone total hip replacement 1 year previously at the Veterans' Affairs Medical Center. Shortly after surgery, the ...

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