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Specificity of Trypsin and Chymotrypsin: Loop-Motion-Controlled Dynamic Correlation as a Determinant
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ABSTRACT
Trypsin and chymotrypsin are both serine proteases with high sequence and structural similarities, but with different substrate specificity. Previous experiments have demonstrated the critical role of the two loops outside the binding pocket in controlling the specificity of the two enzymes. To understand the mechanism of such a control of specificity by distant loops, we have used the Gaussian network model to study the dynamic properties of trypsin and chymotrypsin and the roles played by the two loops. A clustering method was introduced to analyze the correlated motions of ...
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Obituary: Garson Kanin
Newspaper article from: The Independent - London
; GARSON KANIN wrote and directed one of...clerk he formed a group, Garson Kay and his Red Peppers...Academy of Dramatic Arts." Kanin made his Broadway debut in...immediately. His name was Garson Kanin and he was to be my right...
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Playwright Garson Kanin, 86
Newspaper article from: Chicago Sun-Times
; NEW YORK Garson Kanin, 86, a prolific playwright who created...history would have been assured had Mr. Kanin done no more than write and direct "Born...Oscar for the 1950 film version. Mr. Kanin was the author or director of many stage...
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HOLLYWOOD MOURNS GARSON KANIN
News Wire article from: United Press International
; ...Press International 03-14-1999 Hollywood mourns Garson Kanin HOLLYWOOD, March 14 (UPI) _ Hollywood is mourning...of one of its most prolific writers and directors, Garson Kanin. Kanin, a familiar face in Hollywood during the movie...
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Garson Kanin, Creator of 'Born Yesterday,' Dies at 86
Newspaper article from: The Washington Post
; Garson Kanin, 86, a dropout from a Brooklyn high school...City. Versatile as well as prolific, Mr. Kanin was a musician, stage and radio actor...Strategic Services during World War II, Mr. Kanin joined with British director Carol Reed...
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 "Post-Tribune (IN)")
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BROADWAY WRITER, DIRECTOR GARSON KANIN DIES AT 86
Newspaper article from: Post-Tribune (IN)
; ...SLIGHTLY FROM THE PRINTED VERSION. Garson Kanin, a playwright who created the Broadway...Yesterday," died Saturday. He was 86. Kanin died of heart failure at his Manhattan...history would have been assured had Kanin done no more than write and direct...
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`Born Yesterday' playwright Garson Kanin, 86, dies
Newspaper article from: The Milwaukee Journal Sentinel
; Garson Kanin, a prolific playwright who created the...an Oscar for the movie version in 1950. Kanin was the author or director of numerous stage...Oscar. Gordon died in 1985. In 1990, Kanin married actress Marian Seldes. He wrote...
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Playwright Kanin dies
Newspaper article from: Sunday Gazette-Mail
; NEW YORK - Garson Kanin, a prolific playwright who created the...Yesterday," died Saturday. He was 86. Kanin died of heart failure at his Manhattan...entertainment history would have been assured had Kanin done no more than write and direct "Born...
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Kanin's `Born Yesterday' is reborn at Steppenwolf
Newspaper article from: Chicago Sun-Times
; ...Academy of Dramatic Arts in New York, Garson Kanin worked as a fifth banana in a burlesque...aspirations beyond that place." Kanin didn't stay at that job very long...that girl fused with my story," Kanin said. "And out of it came the soul...
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Obituaries in the News
News Wire article from: AP Online
; ...physics at Stanford and the University of Michigan before coming to the University of Arizona in 1973. Garson Kanin NEW YORK (AP) -- Garson Kanin, a prolific playwright who created the Broadway and Hollywood classic ``Born Yesterday,'' died...
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`Born Yesterday' Creator Dies at 86
News Wire article from: AP Online
; ...Creator Dies at 86 NEW YORK (AP) -- Garson Kanin, a prolific playwright who created...Yesterday,'' died today. He was 86. Kanin died of heart failure at his Manhattan...history would have been assured had Kanin done no more than write and direct...
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