Intra- and Inter-Islet Synchronization of Metabolically Driven Insulin Secretion

From: Biophysical Journal | Date: July 1, 2005| Author: Bertram, Richard; Sherman, Arthur; Pedersen, Morten Gram | Copyright information

ABSTRACT

Insulin secretion from pancreatic β-cells is pulsatile with a period of 5-10 min and is believed to be responsible for plasma insulin oscillations with similar frequency. To observe an overall oscillatory insulin profile it is necessary that the insulin secretion from individual β-cells is synchronized within islets, and that the population of islets is also synchronized. We have recently developed a model in which pulsatile insulin secretion is produced as a result ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and journal articles from HighBeam Research

Intra- and Inter-Islet Synchronization of Metabolically Driven Insulin Secretion
Biophysical Journal ; ABSTRACT Insulin secretion from pancreatic β-cells is pulsatile with a period of 5-10 min and is believed to be responsible for plasma insulin oscillations with similar frequency. To observe an overall oscillatory insulin profile it is necessary that the insulin secretion from individual
Low-Protein Diets Reduce PKA[alpha] Expression in Islets from Pregnant Rats1,2
The Journal of Nutrition ; ABSTRACT We investigated the effect of protein restriction on insulin secretion and the expression of protein kinase (PK)Aα and PKCα in islets from control and pregnant rats. Adult control nonpregnant (CN) and control pregnant (CP) rats were fed a normal-protein diet (17 whereas
Decreased Insulin Secretion in Islets from Rats Fed a Low Protein Diet Is Associated with a Reduced PKA[alpha] Expression1
The Journal of Nutrition ; ABSTRACT A low protein diet has been shown to affect the amount and activity of several enzymes and to decrease insulin secretion by islets isolated from rats fed such a diet. To understand the mechanisms involved in this phenomenon, we investigated the effects of forskolin, a stimulator of
Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation
The Journal of Nutrition ; Nutrient-Gene Interactions Expression of PDX-1 Is Reduced in Pancreatic Islets from Pups of Rat Dams Fed a Low Protein Diet during Gestation and Lactation1 ABSTRACT Intrauterine and early postnatal malnutrition has profound consequences on fetal and postnatal development in both humans and animals.
A protein-restricted diet during pregnancy alters in vitro insulin secretion from islets of fetal winstar rats
The Journal of Nutrition ; A Protein-Restricted Diet during Pregnancy Alters in Vitro Insulin Secretion from Islets of Fetal Wistar Rats1,2 ABSTRACT Previous studies indicate that insulin secretion from the fetuses of dams fed a low protein (LP) diet is reduced in response to leucine or arginine. The aim of this study was to
Glucagon-Like Peptide-1 and Energy Homeostasis1,2
The Journal of Nutrition ; Abstract A growing body of evidence demonstrates the role of gut-derived hormones in the control of energy homeostasis. Among those intestinal signals, physiological and therapeutic interest has been drawn to glucagon-like peptide-1 (GLP-1). The main reasons are that this hormone 1) is secreted by
A Low Protein Diet Alters Gene Expression in Rat Pancreatic Islets1
The Journal of Nutrition ; ABSTRACT Insulin secretion is regulated mainly by circulating nutrients, particularly glucose, and is also modulated by hormonal and neuronal inputs. Nutritional alterations during fetal and early postnatal periods, induced by either low protein or energy-restricted diets, produce [beta]-cell
The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction
The Journal of Nutrition ; The Role of Long-Chain Fatty Acyl-CoA Esters in beta-Cell Signal Transduction 1,2 ABSTRACT Glucose-induced insulin secretion is associated with inhibition of free fatty acid (FFA) oxidation, increased esterification and complex lipid formation by pancreatic beta-cells. Abundant evidence favors a
Hyperinsulinism in Infancy and Childhood: When an Insulin Level Is Not Always Enough
Clinical Chemistry ; BACKGROUND: Hypoglycemia in infants and children can lead to seizures, developmental delay, and permanent brain damage. Hyperinsulinism (HI) is the most common cause of both transient and permanent disorders of hypoglycemia. HI is characterized by dysregulated insulin secretion, which results in
Insulin secretion and sensitivity in children on cyclic total parenteral nutrition
JPEN, Journal of Parenteral and Enteral Nutrition ; Anne Lienhardt, MD*; Benjamin Rakotoambinina, MD*; Virginie Colomb, MDt; Sihem Souissi, MD*; Evelyne Sadoun, MDt; Olivier Goulet, MDt; Jean-Jacques Robert, MD, PhD*; and Claude Ricour, MDt ABSTRACT. Background: Some children receiving total parenteral nutrition (TPN) have abnormal glucose