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Severe Asthma in Adults
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Severe asthma remains poorly understood and frustrating to care for, partly because it is a heterogeneous disease. Patients with severe asthma disproportionately consume health care resources related to asthma. Severe asthma may develop over time, or shortly after onset of the disease. The genetic and environmental elements that may be most important in the development of severe disease are poorly understood, but likely include both allergic and nonallergic elements. Physiologically, these pa...
Related newspaper, magazine, and journal articles from HighBeam Research
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Severe Asthma in Adults
American Journal of Respiratory and Critical Care Medicine
; Severe asthma remains poorly understood and frustrating to care for, partly because it is a heterogeneous disease. Patients with severe asthma disproportionately consume health care resources related to asthma. Severe asthma may develop over time, or shortly after onset of the disease. The genetic
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Phenotypes in Asthma
American Journal of Respiratory and Critical Care Medicine
; Useful Guides for Therapy, Distinct Biological Processes, or Both? Webster's New Collegiate Dictionary defines the word "phenotype" as "the visible properties of an organism that are produced by the interaction of genotype and the environment" (1). This definition of phenotypes would appear to be
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Diminished Lipoxin Biosynthesis in Severe Asthma
American Journal of Respiratory and Critical Care Medicine
; Rationale and Objectives: Severe asthma is characterized by increased airway inflammation that persists despite therapy with corticosteroids. It is not, however, merely an exaggeration of the eosinophilic inflammation that characterizes mild to moderate asthma; rather, severe asthma presents unique
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Epithelial Cell Proliferation Contributes to Airway Remodeling in Severe Asthma
American Journal of Respiratory and Critical Care Medicine
; Rationale: Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction. Objectives: To evaluate if there are structural and functional differences in the airway epithelium in severe asthma associated with airway remodeling. Methods: In
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"Refractory" Eosinophilic Airway Inflammation in Severe Asthma: Effect of Parenteral Corticosteroids
American Journal of Respiratory and Critical Care Medicine
; It has been suggested that patients with refractory eosinophilic airway inflammation represent a separate "eosinophilic" asthma phenotype associated with increased morbidity and a poor prognosis. To investigate whether persistent eosinophilia in these patients is a fixed feature or can still be
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UW PROFESSOR PUTS FOCUS ON SEVERE ASTHMA PHYSIOLOGIST FINDS EVIDENCE THAT SEVERE ASTHMA MAY BE DIFFERENT FORM OF THE DISEASE.(LOCAL)
Wisconsin State Journal (Madison, WI)
; Byline: ANITA CLARK aclark@madison.com 608-252-6138 As nearly 20 million Americans know firsthand, asthma is a frustrating and frightening disease. Doctors don't know why it's been increasing since the early 1980s. Most people with this chronic disease have mild to moderate symptoms that are well
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Update in Asthma 2005
American Journal of Respiratory and Critical Care Medicine
; Asthma, an enormously common illness, has been a focus of research studies, many published in the journals of the American Thoracic Society and/or American Lung Association for more than 100 yr (1). In 2005, ongoing research focused on several emerging areas, including studies on the use of
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Relative Corticosteroid Insensitivity of Peripheral Blood Mononuclear Cells in Severe Asthma
American Journal of Respiratory and Critical Care Medicine
; Rationale and Objectives: Patients with severe asthma have a poor therapeutic response to corticosteroid therapy, and corticosteroid responsiveness cannot be easily measured in these patients. We hypothesized that this poor response is associated with a reduced effect of corticosteroids to inhibit
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"Refractory" Eosinophilic Airway Inflammation in Severe Asthma
American Journal of Respiratory and Critical Care Medicine
; To the Editor. The recent study by ten Brinke and colleagues (1) should make us pause to consider the direction in which research into the mechanisms of refractory asthma is heading. Their data demonstrate that use of intramuscular triamcinolone, in patients with refractory asthma, leads to a
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Update in Asthma 2007
American Journal of Respiratory and Critical Care Medicine
; A major event in asthma was the publication of the third edition of the updated National Asthma Education and Prevention Program (NAEPP) ''Guidelines on the Diagnosis and Management of Asthma'' by the National, Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (1). The
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