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Factors That Control the Tissue-Specific Transcription of the Gene for Phosphoenolpyruvate Carboxykinase-C
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ABSTRACT Transcription of the gene for PEPCK-C occurs in a number of mammalian tissues, with highest expression occurring in the liver, kidney cortex, and white and brown adipose tissue. Several hormones and other factors, including glucagon, epinephrine, insulin, glucocorticoids and metabolic acidosis, control this process in three responsive tissues, liver, adipose tissue, and kidney cortex. Expression of the gene in these three tissues in regulated in a different manner, responding to the ...
Related newspaper, magazine, and journal articles from HighBeam Research
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Retinoids Upregulate Phosphoenolpyruvate Carboxykinase and Glyceroneogenesis in Human and Rodent Adipocytes1,2
The Journal of Nutrition
; Abstract Glyceroneogenesis is an important metabolic pathway for fatty acid reesterification in adipose tissue, thereby reducing fatty acid, release. Glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), which is the key enzyme in this pathway, are both regulated by a series
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Somatotropin regulates adipose tissue metabolism in neonatal swine
The Journal of Nutrition
; Somatotropin Regulates Adipose Tissue Metabolism in Neonatal Swine1'2'3 ABSTRACT Somatotropin (ST) reduces lipid deposition in growing and adult animals, but its effect in neonatal pigs is not clear. In this study, we tested the hypothesis that ST inhibits lipid deposition in neonatal pig adipose
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Expression of Interleukin-6 Is Greater in Preadipocytes than in Adipocytes of 3T3-L1 Cells and C57BL/6J and ob/ob Mice
The Journal of Nutrition
; ABSTRACT Inflammation plays a major role in the development of chronic diseases such as cardiovascular disease and Type 2 diabetes. Further, it was demonstrated that obese animals and humans have significantly higher levels of circulating proinflammatory cytokines, such as interleukin-6 (IL-6). The
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Insulin increases lipogenic enzyme activity in human adipocytes in primary culture
The Journal of Nutrition
; Fatty acid and triacylglycerol synthesis for energy storage are regulated in response to hormonal and nutritional states. Adipose tissue is the major site far energy storage and plays an important role in maintaining glucose homeostasis. Abnormalities in hormonal and nutritional regulation of this
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Adipose tissue as an endocrine organ.(Tips)
American Family Physician
; Adipose tissue has active metabolic properties that contribute to the clinical effects of obesity. The contents of adipose tissue (including adipocytes, connective tissue matrix, nerve tissue, immune cells, stromovascular cells, and immune cells) work together to respond to multiple body signals by
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Adipocytokines and Cancer
Physiological Research
; Summary Adipose tissue-produced hormones significantly affect the metabolism of lipids and carbohydrates as well as numerous other processes in human body. It is generally accepted that endocrine dysfunction of adipose tissue may represent one of the causal links between obesity and insulin
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Stereospecific incorporation of palmitoyl, oleoyl and linoleoyl moieties into adipose tissue triacylglycerols of rats results in constant sn-1:sn-2:sn-3 in rats fed...
The Journal of Nutrition
; Nutrient Metabolism ABSTRACT We report the stereospecific (sn-1, sn-2, sn-3) distribution of fatty acids in subcutaneous adipose tissue triacylglycerols of male weaned Wistar rats fed either a standard diet or diets containing, in addition to 20 g corn oil/kg feed, 120 g/kg feed, each, of
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Increased Lipolysis of Subcutaneous Abdominal Adipose Tissue and Altered Noradrenergic Activity in Patients with Cushing's Syndrome: An In-vivo Microdialysis Study
Physiological Research
; Summary Cushing's syndrome is associated with typical central redistribution of adipose tissue. The aim of the study was to assess lipolysis and catecholamines and their metabolites in subcutaneous abdominal adipose tissue using an in-vivo microdialysis technique. Nine patients with Cushing's
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Inconsistent Effect of Nitric Oxide on Lipolysis in Isolated Rat Adipocytes
Physiological Research
; Summary Though two isoforms of nitric oxide synthase, iNOS and eNOS, were reported in adipocytes, the role of NO in adipose tissue is still ambiguous. The aims of the present study were 1) to follow the effect of bacterial lipopolysaccharide (LPS), on 24 h-lipolysis in rat epididymal adipocyte
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Arachidonic Acid in Adipose Tissue Is Associated with Nonfatal Acute Myocardial Infarction in the Central Valley of Costa Rica1
The Journal of Nutrition
; ABSTRACT Arachidonic acid (AA), a precursor of prothrombotic eicosanoids, is potentially atherogenic, but epidemiologic data are scarce. We evaluated the hypothesis that increased AA in adipose tissue is associated with increased risk of nonfatal acute myocardial infarction (MI), and if so, whether
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