DNA Packaging in Bacteriophage: Is Twist Important?

From: Biophysical Journal | Date: June 1, 2005| Author: Spakowitz, Andrew James; Wang, Zhen-Gang | Copyright information

ABSTRACT

We study the packaging of DNA into a bacteriophage capsid using computer simulation, specifically focusing on the potential impact of twist on the final packaged conformation. We perform two dynamic simulations of packaging a polymer chain into a spherical confinement: one where the chain end is rotated as it is fed, and one where the chain is fed without end rotation. The final packaged conformation exhibits distinct differences in these two cases: the packaged conformation f...

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