Numerical Investigation of Sequence Dependence in Homologous Recognition: Evidence for Homology Traps

From: Biophysical Journal | Date: June 1, 2005| Author: Fulconis, Renaud; Dutreix, Marie; Viovy, Jean-Louis | Copyright information

ABSTRACT

During the initial phase of RecA-mediated recombination, known as the search for homology, a single-stranded DNA coated by RecA protein and a homologous double-stranded DNA have to perfectly align and pair. We designed a model for the homology search between short molecules, and performed Monte Carlo Metropolis computer simulations of the process. The central features of our model are 1), the assumption that duplex DNA longitudinal thermal fluctuations are instrumental in the ...

Related newspaper, magazine, and journal articles from HighBeam Research

Input vital to UNC search process.(Triad Classifiedsdeasomeseneral News)
The News & Record (Piedmont Triad, NC) ; Byline: J. BRADLEY WILSON Recent coverage and commentary about the University of North Carolina presidential search requires that I offer supplemental information about the search process. The Presidential Search Committee has and continues to encourage public comment in the search. Opinions and
WVU prof: Reform presidential search.
Dominion Post (Morgantown, WV) ; Byline: Eric Bowen May 11--The search process that named Morgantown lawyer Mike Garrison as WVU president was flawed and needs to be reformed, a WVU professor said Thursday. Sherman Riemenschneider, chair of the WVU mathematics department, said he plans to introduce a motion at the WVU Faculty
NADER TO LEAD A PROTEST OF HARVARD SEARCH PROCESS
The Boston Globe ; Consumer advocate Ralph Nader is scheduled to lead a campus protest at Harvard University tomorrow to press for more student involvement in Harvard's search for a new president. Students at Harvard have been complaining in recent weeks that the search process is too closed, and does not involve any
Altered nuclear distribution of recombination protein RAD51 in maize mutants suggest the involvement of RAD51 in meiotic homology recognition
Plant Cell ; The recombination protein RAD51 is a component of the meiotic recombination pathway and has been proposed to play a role in the homology search, a process by which homologous chromosomes find each other before they pair in the prophase of meiosis. To study the relationship between recombination and
Plante picked to become administrator
The Patriot Ledger Quincy, MA ; 2 selectmen abstain because of search-process concerns Christopher WalkerThe Patriot Ledger Selectmen appointed a town administrator last night despite two board members' lingering concerns about the search process. Bradley Plante, a North Attleboro selectman with 20 years of managerial experience