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The CXCL10/CXCR3 Axis Mediates Human Lung Mast Cell Migration to Asthmatic Airway Smooth Muscle
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Mast cell microlocalization within the airway smooth muscle bundle is an important determinant of the asthmatic phenotype. We hypothesized that mast cells migrate toward airway smooth muscle in response to smooth muscle-derived chemokines. In this study, we investigated (1) chemokine receptor expression by mast cells in the airway smooth muscle bundle in bronchial biopsies from subjects with asthma using immunohistology, (2) the concentration of chemokines in supernatants from stimulated ex v...
Related newspaper, magazine, and journal articles from HighBeam Research
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Early allergy season springs into action
Ophthalmology Times
; Special Sectoin: Ocular Allergies Understanding healing, symptom-mediating roles of mast cells helps in choosing best treatment This year's fierce winter is now about to bring a big dose of misery to the 60 million Americans who suffer from seasonal allergies. Experts predict a fast-peaking,
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Induction of Mast Cell Activation and CC Chemokine Responses in Remodeling Tracheal Allografts
American Journal of Respiratory Cell and Molecular Biology
; ... analysis, and acknowledge the excellent technical assistance of David Dreizin, Tracy L. Evans, Sang H. Sung, Andrew Toy, and Mai Tran. This work was supported by National Institutes of Health grant HL-64897, a research grant from the Research Evaluation and Allocation ...
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Bombesin-like peptides and mast cell responses: Relevance to bronchopulmonary dysplasia?
American Journal of Respiratory and Critical Care Medicine
; Bombesin-like peptides (BLPs) are elevated in newborns who later develop bronchopulmonary dysplasia (BPD). In baboon models, anti-BLP blocking antibodies abrogate BPD. We now demonstrate hyperplasia of both neuroendocrine cells and mast cells in lungs of baboons with BPD, compared with non-BPD
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Mastocytic Enterocolitis: Increased Mucosal Mast Cells in Chronic Intractable Diarrhea
Archives of Pathology & Laboratory Medicine
; Context.-In some adult patients with chronic intractable diarrhea, the diagnosis remains elusive even after detailed evaluations, and colonic or duodenal biopsy specimens may appear unremarkable on routine hematoxylineosin staining. Objectives.-To assess the concentration of mast cells in colonic
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Unmasking mastocytosis.
Dermatology Nursing
; Objectives This educational activity is designed for nurses and other health care providers who care for and educate patients about mastocytosis. An evaluation follows this offering and is designed to test the reader's achievement of the objectives listed below. After studying the information
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Evaluation of Mast Cells in Myeloproliferative Disorders and Myelodysplastic Syndromes
Archives of Pathology & Laboratory Medicine
; * Context.-Mast cells may be increased as a reactive mastocytosis in various hematologic disorders and malignant neoplasms, as well as in systemic mast cell disease (SMCD). There are no statistical differences in mast cell numbers in reactive mastocytosis and SMCD; however, SMCD usually reveals
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NCSU investigates role of mast cell defense
DVM
; RALEIGH, N.C.-Nestled beneath the gills of hybrid striped bass rest some important clues that may someday help treat diseases such as asthma, skin allergies and arthritis in animals and people. Researchers at North Carolina State University have found a famfly of antibiotics inside mast cells or
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Immune cell triggers attack on plaque. (mast cell linked to formation of clot that could cause heart attack) (Brief Article)
Science News
; The sudden, often fatal rupture of plaque clogging an artery involves a host of possible villains, including the scavenging immune cells called macrophages. Now, a Finnish team presents evidence that another immune cell, the mast cell, may also take part in this deadly assault. Atherosclerosis
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The ocular allergic response: A pharmacotherapeutic review
Formulary
; Abstract One of the most common ophthalmic conditions that directs a patient to a primary-care physician or eye-care practitioner is the red, itchy eye. The highest percentage of conjunctivitis is noninfectious or inflammatory, and frequently these cases are allergic in nature. The ophthalmic
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Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis
American Journal of Respiratory Cell and Molecular Biology
; Although mast cell secretion has been intensively studied because of its pivotal role in allergic reactions and its advantages as a physiologic model, the molecular composition of the secretory machine is virtually unknown. In view of the guanine-nucleotide dependency of mast cell exocytosis and
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