Role of Recombinant Activated Factor VII in the Management of Life-threatening Coagulopathic Bleeding

From: Anaesthesia and Intensive Care | Date: April 1, 2005| Author: | Copyright information

Recombinant activated factor VII (rFVIIa, eptacog alfa, NovoSeven®, NovoNordisk, Copenhagen, Denmark) appears to be an effective agent for the correction of a wide range of coagulopathies1. It has been available commercially in Australia since 1998, although at present it is approved by the Therapeutic Goods Administration (TGA) only for use in patients with factor VIII or IX deficiency with inhibitors2. Its use for patients with life-threatening coagulopathic bleeding is increasing, despite being "off-label" for this indication. This is due mainly to the large number of case reports and ...

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