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The effect of relcovaptan (SR 49059), an orally active vasopressin V^sub 1a^ receptor antagonist, on uterine contractions in preterm labor
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Abstract
Relcovaptan (SR 49059) is a non-peptide, orally active vasopressin V^sub 1a^ receptor inhibitor. The effect on uterine contractions in 18 women with preterm labor in pregnancy weeks 32-36 was assessed in a double-blind investigation. The inclusion criterion was at least four regular uterine contractions over 30 min as measured by external tocodynamometry. Twelve patients received at random a single oral dose of 400 mg relcovaptan and six received placebo, and contractions were...
