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RNA-Binding Proteins in Early Development
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ABSTRACT RNA-binding proteins play a major part in the control of gene expression during early development. At this stage, the majority of regulation occurs at the levels of translation and RNA localization. These processes are, in general, mediated by RNA-binding proteins interacting with specific sequence motifs in the 3'-untranslated regions of their target RNAs. Although initial work concentrated on the analysis of these sequences and their trans-acting factors, we are now beginning to ga...
Related newspaper, magazine, and journal articles from HighBeam Research
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RNA-Binding Proteins in Early Development
Critical Reviews in Biochemistry and Molecular Biology
; ABSTRACT RNA-binding proteins play a major part in the control of gene expression during early development. At this stage, the majority of regulation occurs at the levels of translation and RNA localization. These processes are, in general, mediated by RNA-binding proteins interacting with specific
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A simple, mechanistic model for directional instability during mitotic chromosome movements
Biophysical Journal
; ABSTRACT During mitosis, chromosomes become attached to microtubules that emanate from the two spindle poles. Thereafter, a chromosome moves along these microtubule "tracks" as it executes a series of movements that bring it to the spindle equator. After the onset of anaphase, the sister chromatids
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Regulation of membrane transport by rab GTPases
Critical Reviews in Biochemistry and Molecular Biology
; ABSTRACT: Membrane flow through the cell is a highly dynamic process in which intracellular compartments communicate via tubulo-vesicular structures shuttling cargo molecules to their destinations. Transport carriers are formed at a donor compartment and navigate through the cytoplasm to the target
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The Saccharomyces cerevisiae Homolog of p24 Is Essential for Maintaining the Association of p150^sup Glued^ With the Dynactin Complex
Genetics
; ABSTRACT Stu1 is the Saccharomyces cerevisiae member of the CLASP family of microtubule plus-end tracking proteins and is essential for spindle formation. A genomewide screen for gene deletions that are lethal in combination with the temperature-sensitive stu1-5 allele identified ldb18Δ.
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+TIPs and Microtubule Regulation. The Beginning of the Plus End in Plants1
Plant Physiology
; ... tubule and by an array of regulatory proteins termed MAPs (MT-associated proteins). The inherent dynamics, or dynamic ... Shaw et al., 2003). MT dynamics are also regulated by MAPs. Many MAPs bind to the sides of MTs and stabilize, destabilize ...
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Uptake of a fluorescent marker in palnt cells is sensitive to Brefeldin A and Wortmannin
Plant Cell
; We assessed FM1-43 [N-(3-triethylammoniumpropyl)-4-(4-[dibutylamino]styryl)pyridinium dibromide] as a fluorescent endocytosis marker in intact, walled plant cells. At VC, FM1-43 stained the plasma membrane, and after 30 to 120 min of incubation at 26 deg C, FM1-43 labeled cytoplasmic vesicles and
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Regulation of actin dynamics in rapidly moving cells: A quantitative analysis
Biophysical Journal
; ABSTRACT We develop a mathematical model that describes key details of actin dynamics in protrusion associated with cell motility. The model is based on the dendritic-nucleation hypothesis for lamellipodial protrusion in nonmuscle cells such as keratocytes. We consider a set of partial differential
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Decreased distribution of lung epithelial junction proteins after intratracheal antigen or lipopolysaccharide challenge: Correlation with neutrophil influx and levels of BALF sE-Cadherin
American Journal of Respiratory Cell and Molecular Biology
; Distribution of airway functional complex proteins after antigen or lipopolysaccharide challenge in sensitized or naive mice, respectively, was investigated. E-cadherin immunoreactivity was detected continuously along neighboring epithelial cell borders and between adjacent alveolar epithelial
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The Arabidopsis AAA ATPase SKD1 Is Involved in Multivesicular Endosome Function and Interacts with Its Positive Regulator LYST-INTERACTING PROTEIN5(W)
Plant Cell
; In yeast and mammals, the AAA ATPase Vps4p/SKD1 (for Vacuolar protein sorting 4/SUPPRESSOR OF K+ TRANSPORT GROWTH DEFECT1) is required for the endosomal sorting of secretory and endocytic cargo. We identified a VPS4/SKD1 homolog in Arabidopsis thaliana, which localizes to the cytoplasm and to
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Characterization of New Spt3 and TATA-Binding Protein Mutants of Saccharomyces cerevisiae: Spt3-TBP Allele-Specific Interactions and Bypass of Spt8
Genetics
; ABSTRACT The Spt-Ada-Gcn5-acetyltransferase (SAGA) complex of Saccharomyces cerevisiae is a multifunctional coactivator complex that has been shown to regulate transcription by distinct mechanisms. Previous results have shown that the Spt3 and Spt8 components of SAGA regulate initiation of
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