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KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS: Clinical, Diagnostic, and Epidemiological Aspects
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Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few viruses proven to be associated with tumorigenesis in humans. Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease (MCD). Possible associations of KSHV with other clinical settings have been extensively examined. The findings from several of t...
Related newspaper, magazine, and journal articles from HighBeam Research
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KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS: Clinical, Diagnostic, and Epidemiological Aspects
Critical Reviews in Clinical Laboratory Sciences
; Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few viruses proven to be associated with tumorigenesis in humans. Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of primary
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Virology, pathogenetic mechanisms, and associated diseases of Kaposi Sarcoma--associated herpesvirus (human herpesvirus 8)
Mayo Clinic Proceedings
; Kaposi sarcoma-associated herpesvirus (KSHV) is a recently discovered and characterized member of the herpesvirus family. It is one of a few viruses proved to be associated with tumorigenesis in humans. Its causal association with 4 clinical and epidemiologic variants of Kaposi sarcoma (classic,
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Absence of Kaposi's Sarcoma-associated Herpesvirus in Patients with Pulmonary Arterial Hypertension
American Journal of Respiratory and Critical Care Medicine
; Rationale: In addition to Kaposi's sarcoma, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) has been associated with two other diseases: primary effusion lymphoma and the plasma cell variant of multicentric Castleman's disease. Recently, evidence of KSHV infection was reported in plexiform
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Herpesvirus-associated Pulmonary Hypertension?
American Journal of Respiratory and Critical Care Medicine
; Herpesviruses have brilliantly adapted to survive in their host of choice, employing specialized gene products that facilitate their transmission, replication (through cell lysis), and persistence (through latency). Unfortunately, the actions of many of these viral gene products negatively impact
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Induction of human immunodeficiency virus 1 replication by human herpesvirus 8
Archives of Pathology & Laboratory Medicine
; * Background.-Human immunodeficiency virus 1 (HIV1)-infected individuals are commonly infected with herpesviruses, including cytomegalovirus, herpes simplex virus, varicella-zoster virus, and human herpesvirus 8 (HHV8, also known as Kaposi sarcoma-associated herpesvirus [KSHV Previous studies have
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Human herpesvirus 6
Mayo Clinic Proceedings
; Human herpesvirus (HHV) 6 is a beta-herpes, DNA virus. This virus shows closest homology with cytomegalovirus and HHV-7. Infection usually occurs in infants 6 to 24 months of age, and primary infection may result in roseola. HHV-6 infection in infants is the commonest cause of fever-induced
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Herpesvirus 8 inclusions in primary effusion lymphoma: Report of a unique case with T-cell phenotype
Archives of Pathology & Laboratory Medicine
; * We describe a case of primary effusion lymphoma with T-cell phenotype, mixed genotype, and intranuclear her. pesvirus inclusions visible with the light microscope. Cells were studied by immunohistochemical analysis, in situ hybridization, immunoglobulin and T-cell receptor gene re. arrangement,
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Human herpesvirus 8 reactivation and human immunodeficiency virus Type 1 gp120
Archives of Pathology & Laboratory Medicine
; * Context.-Human herpesvirus 8 (HHV-8) is the presumed etiologic agent of Kaposi sarcoma (KS), the most common neoplasm in patients with acquired immunodeficiency syndrome. Current evidence indicates HHV-8 is necessary, but not sufficient, for KS development without the involvement of other
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Early peripheral lymph node involvement of human herpesvirus 8-associated, body cavity-based lymphoma in a human immunodeficiency virus-negative patient
Archives of Pathology & Laboratory Medicine
; Human herpesvirus 8 (HHV-8), or Kaposi sarcoma-associated herpesvirus, is a gamma herpesvirus first detected in a specimen of Kaposi sarcoma from a human immunodeficiency virus (HIV)-positive patient. Human herpesvirus 8 is also found in an unusual clinicopathologic form of body cavity-based B-cell
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Questionable Role of Human Herpesviruses in the Pathogenesis of Kikuchi Disease
Archives of Pathology & Laboratory Medicine
; Context.-Kikuchi disease is a self-limiting febrile lymphadenopathy characterized by a patchy area of apoptosis. Kikuchi disease is thought to be caused by a virus, but this has not been clearly demonstrated. Human herpesviruses 6 and 7 (HHV-6 and HHV-7) are lymphotropic viruses that can induce
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