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Chloride Transport in Nasal Ciliated Cells of Cystic Fibrosis Heterozygotes
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Studying subjects heterozygous for mutations of the cystic fibrosis (CF) gene may help clarify the impact on disease onset of CF transmembrane conductance regulator protein (CFTR-)-dependent chloride secretion. CFTR-mediated chloride transport was evaluated in 52 heterozygous subjects, 32 healthy control subjects, and 77 patients with CF with class I or II mutations. We measured the change in nasal potential difference in response to chloride-free isoproterenol solution for each subject and u...
Related newspaper, magazine, and journal articles from HighBeam Research
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Chloride Transport in Nasal Ciliated Cells of Cystic Fibrosis Heterozygotes
American Journal of Respiratory and Critical Care Medicine
; Studying subjects heterozygous for mutations of the cystic fibrosis (CF) gene may help clarify the impact on disease onset of CF transmembrane conductance regulator protein (CFTRdependent chloride secretion. CFTR-mediated chloride transport was evaluated in 52 heterozygous subjects, 32 healthy
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Treatment of cystic fibrosis in adults.
American Family Physician
; Cystic fibrosis is the most common fatal, autosomal-recessive disease in Caucasians. Five percent of white Americans carry the cystic fibrosis gene, which manifests itself in one of 2,000 live births.(1) The life expectancy of persons with cystic fibrosis has increased, and a larger proportion of
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Cystic Fibrosis: Everything You Need to Know
Journal of the National Medical Association
; Cystic Fibrosis: Everything You Need to Know Edited by Wayne Kepron; New York: Firefly Books, 2004; ISBN 1-55297-7 40-4; 190 pages Cystic fibrosis is the most common autosomal recessive disorder in Caucasian people. Approximately one in 25 Caucasians is a heterozygous carrier for this disorder,
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 "Birmingham Evening Mail (England)")
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Heartache of hidden fate; A group of parents meets once a month in a Birmingham pub to swap stories, laugh and cry. All are parents of children with cystic fibrosis, and have first-hand knowledge of the pain and heartache it brings. Women's Editor DIANE PARKES meets the Caring Friends.
Birmingham Evening Mail (England)
; TRACEY and Brendan Finnegan discovered their son Callum had cystic fibrosis when he was just ten weeks old. But even then it was too late. By that tender age, the youngster's lungs were damaged beyond repair. The couple of Derron Avenue, South Yardley, already had an older son who was healthy, and
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CDC releases recommendations for state newborn screening programs for cystic fibrosis.(Practice Guidelines)
American Family Physician
; The Centers for Disease Control and Prevention (CDC) released recommendations on the screening of newborns for cystic fibrosis. The report includes an evaluation of the benefits and risks of this type of screening. It also provides recommendations on how to effectively implement screening programs
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Cystic Fibrosis Methods and Protocols (Methods in Molecular Medicine, Vol. 70)
Clinical Chemistry
; Cystic Fibrosis Methods and Protocols (Methods in Molecular Medicine, Vol. 70). William R. Skach, ed. Totowa, NJ: Humana Press Inc., 2002, 652 pp., $145.00, hardcover. ISBN 0-89603-897-1. Although this collection of laboratory techniques is directed primarily to research scientists, it has a wealth
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Cystic fibrosis gene and protein identified.
Science News
; Cystic fibrosis gene and protein identified After years of searching through DNA strands, a U.S.-Canadian research team has located the defective gene causing cystic fibrosis and has isolated its protein product. The finding might ultimately lead to new treatments and better genetic counseling for
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Cystic Fibrosis Since 1938
American Journal of Respiratory and Critical Care Medicine
; Cystic fibrosis (CF) was distinguished from celiac disease in 1938. Then, it was a pathologic diagnosis, life expectancy was approximately 6 months, and the autosomal recessive disease was believed to arise from abnormal mucus plugging exocrine ducts. Death often occurred from lung infection.
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Transition of transplant patients with cystic fibrosis to adult care: today's challenges
Progress in Transplantation
; One of the most trying ordeals for patients with cystic fibrosis is moving from one care setting to another. When the patient is facing the crisis of failing health and the need for lung transplantation, the transition can seem even more overwhelming. In Toronto, patients are transferred from
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Nitric oxide deficiency contributes to impairment of airway relaxation in cystic fibrosis mice
American Journal of Respiratory Cell and Molecular Biology
; The pulmonary disease of cystic fibrosis (CF) is characterized by persistent airway obstruction, which has been attributed to chronic endobronchial infection and inflammation. The levels of exhaled nitric oxide (NO) are reduced in CF patients, which could contribute to bronchial obstruction through
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