Risk of Anaphylaxis After Reexposure to Intravenous Lepirudin in Patients With Current or Past Heparin-Induced Thrombocytopenia

From: Mayo Clinic Proceedings | Date: April 1, 2005| Author: Deitcher, Steven R; Cardenas, Gustavo A | Copyright information

OBJECTIVE: To retrospectively assess the signs and symptoms indicative of adverse reactions to repeated exposures to lepirudin In patients with heparin-induced thrombocytopenia who received at least 2 courses of lepirudin therapy.

PATIENTS AND METHODS: Medical records were retrospectively assessed from adult patients who received at least 2 courses of lepirudin therapy separated by at least 1 week between January 1999 and June 2002 at The Cleveland Clinic, Cleveland, Ohio. We evaluated...

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