Homology Modeling and Molecular Dynamics Simulations of Transmembrane Domain Structure of Human Neuronal Nicotinic Acetylcholine Receptor From: Biophysical Journal | Date: February 1, 2005| Author: Tang, Pei; Xu, Yan; Saladino, Alexander C | Copyright Biophysical Society Feb 2005. Provided by ProQuest LLC.Copyright information

ABSTRACT

A three-dimensional model of the transmembrane domain of a neuronal-type nicotinic acetylcholine receptor (nAChR), (α4)^sub 2^(β2)^sub 3^, was constructed from a homology structure of the muscle-type nAChR recently determined by cryoelectron microscopy. The neuronal channel model was embedded in a fully hydrated DMPC lipid bilayer, and molecular-dynamics simulations were performed for 5 ns. A comparative analysis of the neuronal- versus muscle-type nAChR models revea...

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