Omalizumab (rhuMAb-E25)

From: Formulary | Date: August 1, 2001| Author: | Copyright information

A recombinant humanized monoclonal antibody for the treatment of refractory asthma

ABSTRACT

While many factors are associated with the development of asthma, IgE-dependent allergy is a major component of airway inflammation and is very common in patients with asthma. Involvement of inflammatory cells and inflammatory mediators is dependent on binding of allergen-specific immunoglobulin E (IgE) to target cells. An innovative approach to asthma therapy involves neutralizing circulating IgE via subcutaneous injection of an anti-IgE antibody-rhuMAb-E25, or omalizumab-every 2 to 4 weeks. In ...

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