Interdisciplinary Research

From: The Scientist | Date: January 17, 2005| Author: | Copyright information

BRIEFS

These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature-awareness tool (www.facultyof1000.com).

R. Ando et al., "Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting," Science, 306:1370-3, Nov. 19, 2004.

The authors describe a new fiuorophore (Dronpa) that has a high quantum yield as well as being remarkably photochromic. Dronpa can be interconverted between bright (fluorescent) and dark (nonfluorescent) states by light of different wavelengths and so can be highlighted, erased, and highlighted again in a ...

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Atomic resolution of large ribosomal subunit reveals structure
; ...activity responsible for peptide bond formation that occurs during messenger...substrate parts involved in peptide bond formation and therefore could be helping...general base catalysis of peptide bond formation.3 Further studies from the...
The Ribosomal Peptidyl Transferase Center: Structure, Function, Evolution, Inhibition
; ...reactions of protein synthesis: peptide bond formation and peptide release. The...catalyst that accelerates peptide bond formation primarily by substrate positioning...KEYWORDS ribosome, ribozyme, peptide bond formation, peptide release, ...
Unfolding Catalytic Routes to APIs
; ...Metal-catalyzed hydrogen-mediated C-C bond formation Catalytic hydrogenation is widely...with concomitant carbon-carbon (C-C) bond formation has been limited. Hydrogen-mediated C-C bond formation has been used for alkene hydroformylation...
Neutrophil Adhesive Contact Dependence on Impingement Force
; ...forces. In the present study we examine bond formation between β^sub 2^-integrins on...conformation of the integrins, and bond formation was assessed by measuring the probability...a given contact stress, the rate of bond formation increases linearly with contact area...
Good timing. (measurement of chemical bond formation in a liquid)
; ...xenon atom (Chemical Physics Letters, 1993, 206, 475-82). As bond formation times go this is a relatively short one, says Apkarian...bond has been formed. This, the first direct observation of bond formation between two different substances, is particularly significant...
C-C bond formation: Young Chemists' Panel, 2 December 2002. (Reports).
; ...Chemists' Panel (YCP) review meeting focused on advances in CC bond formation. The meeting featured five comprehensive reviews of C-C...day's proceedings was a lecture on the application of C-C bond formation to natural product synthesis. The meeting was extremely...
Conformational Effects on Tryptophan Fluorescence in Cyclic Hexapeptides
; ABSTRACT The peptide bond quenches tryptophan fluorescence...identical amino acid composition, and peptide bond as the only known quenching group...demonstrates the dominant role of peptide bond quenching in tryptophan fluorescence...
Mechanism for Intein C-Terminal Cleavage: A Proposal from Quantum Mechanical Calculations
; ...base. The protonation of the scissile peptide bond nitrogen by a hydronium ion is an important...succinimide formation and simultaneous peptide bond cleavage. The computed reaction energy...C-terminal cleavage is isolated, and the peptide bond between the C-terminal of the intein...
Organic chemistry.
; ...nucleophilicity remains, allowing a second bond formation to proceed by adding an electrophile...1451) provides another example of bond-formation which combines two anions. The sequential...17)), followed by intramolecular C-C bond formation with extrusion of S[O.sub.2] to give...
Carbon-carbon bond-forming reactions using alkyl fluorides *.(Report)
; ...summarizes our recent results on C-C bond formation reactions using alkyl fluorides mostly...usefulness of alkyl fluorides in C-C bond formation reactions and provide a promising method...pathways, are discussed. Keywords: bond formation; carbon-carbon bond; alkyl fluorides...