Inhibitory Action of Conjugated C^sub 18^-Fatty Acids on DNA Polymerases and DNA Topoisomerases From: Lipids | Date: October 1, 2004| Author: Mizushina, Yoshiyuki; Tsuzuki, Tsuyoshi; Eitsuka, Takahiro; Miyazawa, Teruo; Et al | Copyright AOCS Press Oct 2004. Provided by ProQuest LLC.Copyright information

ABSTRACT: We reported previously that unsaturated linear-chain FA of the cis-configuration with a C^sub 18^-hydrocarbon chain such as linoleic acid (18:2Δ9c, 12c) could potently inhibit the activities of mammalian DNA polymerases and DNA topoisomerases, but their saturated forms could not. There are chemically two classes of unsaturated FA, normal and conjugated, but only the conjugated forms show potent antitumor activity. In this report, we study the inhibitory effects of chemically sy...